The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200274
Abstract: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a mitochondrial 1‐carbon metabolism enzyme, which is an attractive anticancer drug target as it is highly upregulated in cancer but is not expressed in healthy adult cells. Selective MTHFD2 inhibitors… read more here.
Keywords: mthfd2l; isoform selective; structure; structure human ... See more keywords
The first structure of an active mammalian dCTPase and its complexes with substrate analogues and products.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.01.005
Abstract: Precise regulation of dNTPs within the cellular nucleotide pool is essential for high accuracy of DNA replication and is critical for retaining the genomic integrity. Recently, human dCTPase (deoxycytidine triphosphatase), also known as DCTPP1 (human… read more here.
Keywords: mammalian dctpase; first structure; structure active; dctpase ... See more keywords
The first structure-activity relationship study of oxytocin as a positive allosteric modulator for the µ opioid receptor
Sign Up to like & getrecommendations! Published in 2022 at "Peptides"
DOI: 10.2139/ssrn.4182107
Abstract: Positive allosteric modulators (PAMs) of G protein-coupled receptors (GPCRs) have drawn attention as novel drug candidates. PAMs can enhance the activities of endogenous agonists which are not only secreted at appropriate times and in parts… read more here.
Keywords: structure; opioid receptor; first structure; activity ... See more keywords