LAUSR

Juniperanol: First total synthesis and evaluation in Type 2 Diabetes disease.

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1 Published in 2019 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2019.103243

Abstract: The first total synthesis of juniperanol, the tricyclic sesquiterpenoid enantiomer of α-cedrol is described. The synthesis relies on stereoselective gold-catalyzed Ohloff-type propargylic ester rearrangement performed on a 10 g scale, and a carbocationic cascade in the… read more here.

Keywords: juniperanol; juniperanol first; first total; total synthesis ... See more keywords

The first total synthesis of lembehyne B

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1 Published in 2017 at "Mendeleev Communications"

DOI: 10.1016/j.mencom.2017.03.004

Abstract: The total synthesis of lembehyne B was accomplished in five steps in 51% total yield. The cross-cyclomagnesiation of two allenic components, nonadeca-1,2-diene and pentadeca-13,14-dien-1-ol tetrahydropyranyl ether, with EtMgBr in the presence of Mg and Cp2TiCl2… read more here.

Keywords: synthesis lembehyne; total synthesis; synthesis; first total ... See more keywords

First total synthesis of cyclic pentadepsipeptides Hikiamides A–C

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0 Published in 2018 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2018.01.096

Abstract: Abstract The first total syntheses of naturally occurring cyclodepsipeptides Hikiamides A–C are described. The key linear pentapeptide precursors, prepared efficiently via Fmoc-solid-phase synthesis, were cyclized in dilute solution to provide the target Hikiamides A–C. The… read more here.

Keywords: synthesis cyclic; pentadepsipeptides hikiamides; first total; total synthesis ... See more keywords

First total synthesis of the β-carboline alkaloids trigonostemine A, trigonostemine B and a new synthesis of pityriacitrin and hyrtiosulawesine

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0 Published in 2019 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2019.04.044

Abstract: Abstract The total synthesis of four natural products, trigonostemine A, trigonostemine B, pityriacitrin, and hyrtiosulawesine was accomplished. The key intermediates, variously substituted 1-formyl-β-carbolines, were prepared in five steps via a novel synthetic approach using readily… read more here.

Keywords: trigonostemine trigonostemine; synthesis; first total; pityriacitrin hyrtiosulawesine ... See more keywords

First total synthesis of versicotide D and analogs

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1 Published in 2019 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2019.151281

Abstract: Abstract The first total synthesis of cyclotetrapeptide versicotide D has been achieved in 21% overall yield using solid phase peptide synthesis and solution cyclization. In addition, in the search for candidates of antimalarial new drugs,… read more here.

Keywords: versicotide; versicotide analogs; first total; total synthesis ... See more keywords

First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J

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1 Published in 2020 at "ACS Omega"

DOI: 10.1021/acsomega.0c01672

Abstract: The first total synthesis of flavesines G and J, natural products exhibiting antiviral activity against hepatitis B virus, is described. A robust, protecting-group-free route starting from commercially available natural product 9-azajulolidine allowed us to obtain… read more here.

Keywords: cytotoxicities flavesines; first total; synthesis vitro; total synthesis ... See more keywords

First total synthesis of chromanone A, preparation of related compounds and evaluation of their antifungal activity against Candida albicans, a biofilm forming agent

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0 Published in 2021 at "RSC Advances"

DOI: 10.1039/d1ra02553h

Abstract: A straightforward and convenient approach for the first total syntheses of chromanone A and a related 7-OMe substituted natural product is reported. These unique C-3 substituted 2-hydroxymethyl chromones were recently isolated as fungal metabolites. Chromanone… read more here.

Keywords: forming agent; chromanone; biofilm forming; first total ... See more keywords

First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine

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0 Published in 2017 at "Synthesis"

DOI: 10.1055/s-0036-1588752

Abstract: A synthetic sequence to the benzonaphthyridinone framework is described. The key step is a one-pot, base-catalyzed vicarious nucleophilic substitution followed by ring closure. Additionally, the synthesis represents the application of a vicarious nucleophilic substitution in… read more here.

Keywords: total synthesis; first total; synthesis cytotoxic; aaptamine ... See more keywords

First Total Synthesis of (±)-Rhodoconferimide

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0 Published in 2017 at "Synthesis"

DOI: 10.1055/s-0036-1590944

Abstract: Starting from vanillin and dimethyl maleate, a concise and efficient racemic total synthesis of the potent antioxidant marine natural product (±)-rhodoconferimide has been carried out via the Wittig reaction, catalytic hydrogenation, selective brominations, and imide… read more here.

Keywords: total synthesis; synthesis; synthesis rhodoconferimide; first total ... See more keywords

First Total Synthesis of Oxirapentyn D, a Highly Oxidized Chromene Natural Product

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1 Published in 2018 at "Synlett"

DOI: 10.1055/s-0036-1591563

Abstract: The first total synthesis of oxirapentyn D from myo-inositol has been achieved by utilizing chelation-directed bridgehead lithiation of a hydrazone derivative. read more here.

Keywords: first total; oxirapentyn highly; synthesis oxirapentyn; total synthesis ... See more keywords

First Total Synthesis of 7-Isovaleryloxy-8-methoxygirinimbine

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0 Published in 2018 at "Synthesis"

DOI: 10.1055/s-0037-1609717

Abstract: We describe the first total synthesis of the pyrano[3,2-a]carbazole alkaloid 7-isovaleryloxy-8-methoxygirinimbine, using a palladium(II)-catalyzed double C–H-bond activation for construction of the carbazole framework and a phenylboronic acid catalyzed annulation of the pyran ring as key… read more here.

Keywords: first total; isovaleryloxy methoxygirinimbine; total synthesis; synthesis ... See more keywords