First Total Synthesis of Inaoside A
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DOI: 10.1002/ajoc.202400547
Abstract: The first total synthesis of inaoside A, an α‐D‐ribofuranoside isolated by our group from the edible mushroom Laetiporus cremeiporus, is described. The key reaction was an α‐selective Schmidt glycosylation. Most reported syntheses of ribofuranosides following… read more here.
Keywords: synthesis inaoside; total synthesis; first total; glycosylation ... See more keywords
Juniperanol: First total synthesis and evaluation in Type 2 Diabetes disease.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103243
Abstract: The first total synthesis of juniperanol, the tricyclic sesquiterpenoid enantiomer of α-cedrol is described. The synthesis relies on stereoselective gold-catalyzed Ohloff-type propargylic ester rearrangement performed on a 10 g scale, and a carbocationic cascade in the… read more here.
Keywords: juniperanol; juniperanol first; first total; total synthesis ... See more keywords
The first total synthesis of lembehyne B
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DOI: 10.1016/j.mencom.2017.03.004
Abstract: The total synthesis of lembehyne B was accomplished in five steps in 51% total yield. The cross-cyclomagnesiation of two allenic components, nonadeca-1,2-diene and pentadeca-13,14-dien-1-ol tetrahydropyranyl ether, with EtMgBr in the presence of Mg and Cp2TiCl2… read more here.
Keywords: synthesis lembehyne; total synthesis; synthesis; first total ... See more keywords
First total synthesis of cyclic pentadepsipeptides Hikiamides A–C
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.01.096
Abstract: Abstract The first total syntheses of naturally occurring cyclodepsipeptides Hikiamides A–C are described. The key linear pentapeptide precursors, prepared efficiently via Fmoc-solid-phase synthesis, were cyclized in dilute solution to provide the target Hikiamides A–C. The… read more here.
Keywords: synthesis cyclic; pentadepsipeptides hikiamides; first total; total synthesis ... See more keywords
First total synthesis of the β-carboline alkaloids trigonostemine A, trigonostemine B and a new synthesis of pityriacitrin and hyrtiosulawesine
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.04.044
Abstract: Abstract The total synthesis of four natural products, trigonostemine A, trigonostemine B, pityriacitrin, and hyrtiosulawesine was accomplished. The key intermediates, variously substituted 1-formyl-β-carbolines, were prepared in five steps via a novel synthetic approach using readily… read more here.
Keywords: trigonostemine trigonostemine; synthesis; first total; pityriacitrin hyrtiosulawesine ... See more keywords
First total synthesis of versicotide D and analogs
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151281
Abstract: Abstract The first total synthesis of cyclotetrapeptide versicotide D has been achieved in 21% overall yield using solid phase peptide synthesis and solution cyclization. In addition, in the search for candidates of antimalarial new drugs,… read more here.
Keywords: versicotide; versicotide analogs; first total; total synthesis ... See more keywords
First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J
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DOI: 10.1021/acsomega.0c01672
Abstract: The first total synthesis of flavesines G and J, natural products exhibiting antiviral activity against hepatitis B virus, is described. A robust, protecting-group-free route starting from commercially available natural product 9-azajulolidine allowed us to obtain… read more here.
Keywords: cytotoxicities flavesines; first total; synthesis vitro; total synthesis ... See more keywords
First total synthesis of chromanone A, preparation of related compounds and evaluation of their antifungal activity against Candida albicans, a biofilm forming agent
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DOI: 10.1039/d1ra02553h
Abstract: A straightforward and convenient approach for the first total syntheses of chromanone A and a related 7-OMe substituted natural product is reported. These unique C-3 substituted 2-hydroxymethyl chromones were recently isolated as fungal metabolites. Chromanone… read more here.
Keywords: forming agent; chromanone; biofilm forming; first total ... See more keywords
First total synthesis of caerulomycin K: a case study on selective, multiple C–H functionalizations of pyridines
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DOI: 10.1039/d4ra00589a
Abstract: Caerulomycins, natural alkaloids with antimicrobial properties, have been previously synthesized starting with highly pre-functionalized building blocks or requiring many functional group manipulations. In this work, we report the first total synthesis of caerulomycin K, a… read more here.
Keywords: caerulomycin case; total synthesis; first total; synthesis caerulomycin ... See more keywords
First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine
Sign Up to like & getrecommendations! Published in 2017 at "Synthesis"
DOI: 10.1055/s-0036-1588752
Abstract: A synthetic sequence to the benzonaphthyridinone framework is described. The key step is a one-pot, base-catalyzed vicarious nucleophilic substitution followed by ring closure. Additionally, the synthesis represents the application of a vicarious nucleophilic substitution in… read more here.
Keywords: total synthesis; first total; synthesis cytotoxic; aaptamine ... See more keywords
First Total Synthesis of (±)-Rhodoconferimide
Sign Up to like & getrecommendations! Published in 2017 at "Synthesis"
DOI: 10.1055/s-0036-1590944
Abstract: Starting from vanillin and dimethyl maleate, a concise and efficient racemic total synthesis of the potent antioxidant marine natural product (±)-rhodoconferimide has been carried out via the Wittig reaction, catalytic hydrogenation, selective brominations, and imide… read more here.
Keywords: total synthesis; synthesis; synthesis rhodoconferimide; first total ... See more keywords