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   Articles with "fisetin" as a keyword



Fisetin Clears Senescent Cells Through the Pi3k‐Akt‐Bcl‐2/Bcl‐xl Pathway to Alleviate Diabetic Aortic Aging

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recommendations! Published in 2025 at "Phytotherapy Research"

DOI: 10.1002/ptr.8507

Abstract: Vascular aging is a major contributor to age‐related cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) induced early arterial aging and excessive senescent cells (SCs) burden in vessels. Inhibiting cellular senescence or eliminating SCs… read more here.

Keywords: senescent cells; bcl bcl; aortic aging; fisetin ... See more keywords

Fisetin, a plant flavonoid ameliorates doxorubicin-induced cardiotoxicity in experimental rats: the decisive role of caspase-3, COX-II, cTn-I, iNOs and TNF-α

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recommendations! Published in 2018 at "Molecular Biology Reports"

DOI: 10.1007/s11033-018-4450-y

Abstract: Doxorubicin (DOX) is a widely used anthracycline antibiotic for the management of carcinoma. However, it is associated with cardiotoxicity. Fisetin is a plant flavonoid reported to have anti-inflammatory and antiapoptotic potential. To evaluate the cardioprotective… read more here.

Keywords: dox induced; caspase; cardiotoxicity; fisetin ... See more keywords

Protective Effects of Fisetin on Hepatic Ischemia-reperfusion Injury Through Alleviation of Apoptosis and Oxidative Stress.

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recommendations! Published in 2021 at "Archives of medical research"

DOI: 10.1016/j.arcmed.2020.10.009

Abstract: BACKGROUND AND AIMS Hepatic ischemia-reperfusion injury (IRI) is the main leading cause of morbidity and mortality of patients after liver surgery and transplantation. Fisetin, a kind of flavonoid, has been reported to protect against myocardial… read more here.

Keywords: effects fisetin; apoptosis; fisetin; ischemia reperfusion ... See more keywords

Extenuation of in utero toxic effects of MeHg in the developing neurons by Fisetin via modulating the expression of synaptic transmission and plasticity regulators in hippocampus of the rat offspring.

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recommendations! Published in 2019 at "Chemico-biological interactions"

DOI: 10.1016/j.cbi.2019.03.014

Abstract: The neurotoxic environmental contaminant, methylmercury (MeHg), has shown to have detrimental effects on the developing brain when exposed during gestation. We have shown in our earlier studies that gestational administration of 3,3',4',7-Tetrahydroxyflavone or Fisetin reduces… read more here.

Keywords: transmission; fisetin; rat; toxic effects ... See more keywords

Fisetin inhibits IL‐1&bgr;‐induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice

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recommendations! Published in 2017 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2017.02.009

Abstract: &NA; Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation and inflammation. Fisetin, a polyphenol extracted from fruits and vegetables, has been reported to have anti‐inflammatory effects. Our study aimed to investigate the… read more here.

Keywords: human osteoarthritis; bgr induced; fisetin; osteoarthritis chondrocytes ... See more keywords

Oral administration of fisetin promotes the induction of hippocampal long-term potentiation in vivo.

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recommendations! Published in 2018 at "Journal of pharmacological sciences"

DOI: 10.1016/j.jphs.2017.12.008

Abstract: To explore memory enhancing effect of the flavonoid fisetin, we investigated the effect of oral administration of flavonoids on the induction of long-term potentiation (LTP) at hippocampal CA1 synapses of anesthetized rats. Among four flavonoids… read more here.

Keywords: term potentiation; induction hippocampal; long term; induction ... See more keywords

Fisetin Attenuates Metabolic Dysfunction in Mice Challenged with a High-Fructose Diet.

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recommendations! Published in 2018 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.8b02140

Abstract: Excess fructose consumption can lead to metabolic syndrome, including insulin resistance, dyslipidemia, and hepatic injury, which are associated with oxidative stress and inflammation. The present study was to investigate whether fisetin improved multiple disturbances induced… read more here.

Keywords: fisetin attenuates; high fructose; fisetin; mice ... See more keywords

Osteogenic Effect of Fisetin Doping in Bioactive Glass/Poly(caprolactone) Hybrid Scaffolds

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recommendations! Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c01109

Abstract: Treating large bone defects or fragile patients may require enhancing the bone regeneration rate to overcome a weak contribution from the body. This work investigates the osteogenic potential of nutrient fisetin, a flavonoid found in… read more here.

Keywords: poly caprolactone; effect; bone; glass poly ... See more keywords

Development of eugenol-fortified fisetin-loaded nano-invasomes gel

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recommendations! Published in 2025 at "Xenobiotica"

DOI: 10.1080/00498254.2025.2478928

Abstract: Abstract The goal of current investigation was to develop eugenol-fortified fisetin nano-invasomes. Fisetin-loaded invasomes were prepared using thin film hydration procedure and evaluated for various parameters. Additionally, the optimised fisetin invasomes formulation (F5) was converted… read more here.

Keywords: nano invasomes; invasomes gel; eugenol fortified; fortified fisetin ... See more keywords

Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles

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recommendations! Published in 2017 at "Drug Delivery"

DOI: 10.1080/10717544.2016.1245366

Abstract: Abstract Fisetin (FST), a potent anticancer phytoconstituent, exhibits poor aqueous solubility and hence poor bioavailability. The aim of the present study is to improve the oral bioavailability of FST by encapsulating into PLGA NPs (poly-lactide-co-glycolic… read more here.

Keywords: oral bioavailability; bioavailability; fst; fisetin ... See more keywords

Fisetin, a potential caloric restriction mimetic, modulates ionic homeostasis in senescence induced and naturally aged rats.

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recommendations! Published in 2019 at "Archives of physiology and biochemistry"

DOI: 10.1080/13813455.2019.1662452

Abstract: Context: Fisetin as a caloric restriction mimetic (CRM) exerts numerous beneficial effects on different aging model systems. The effect of fisetin on erythrocyte membrane functions against induced aging is not very clear. Objectives: The potential… read more here.

Keywords: aged rats; senescence induced; caloric restriction; ionic homeostasis ... See more keywords