Fitness cost of spinosad resistance related to vitellogenin in Frankliniella occidentalis (Pergande).
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.7253
Abstract: BACKGROUND The western flower thrips Frankliniella occidentalis, a worldwide agricultural pest, has developed resistance to an array of insecticides. Spinosad resistance confer an apparent fitness cost in F. occidentalis. In the present study, we compared… read more here.
Keywords: spinosad resistance; resistance; fitness cost; cost spinosad ... See more keywords
Functional characterization and fitness cost of spinosad-resistant alleles in Ceratitis capitata
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pest Science"
DOI: 10.1007/s10340-020-01205-x
Abstract: The sustainability of control programs for the Mediterranean fruit fly, Ceratitis capitata, for citrus crops in Spain has been threatened by the development of resistance to malathion and lambda-cyhalothrin in recent years. Spinosad is widely… read more here.
Keywords: fitness cost; functional characterization; resistant alleles; ceratitis capitata ... See more keywords
Combined over-expression of two cytochrome P450 genes exacerbates the fitness cost of pyrethroid resistance in the major African malaria vector Anopheles funestus
Sign Up to like & getrecommendations! Published in 2021 at "Pesticide Biochemistry and Physiology"
DOI: 10.1016/j.pestbp.2021.104772
Abstract: Metabolic resistance driven by multiple P450 genes is worsening insecticide resistance in malaria vectors. However, it remains unclear whether such multiple over-expression imposes an additive fitness cost in the vectors. Here, we showed that two… read more here.
Keywords: fitness cost; expression; resistance; p450 genes ... See more keywords
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1806109115
Abstract: Significance Protozoal proteasome is a validated target for antimalarial drug development, but species selectivity of reported inhibitors is suboptimal. Here we identify inhibitors with improved selectivity for malaria proteasome β5 subunit over each active subunit… read more here.
Keywords: fitness cost; inhibitor; proteasome; resistance ... See more keywords
Compensatory mutations reducing the fitness cost of plasmid carriage occur in plant rhizosphere communities
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DOI: 10.1093/femsec/fiad027
Abstract: Plasmids drive bacterial evolutionary innovation by transferring ecologically important functions between lineages, but acquiring a plasmid often comes at a fitness cost to the host cell. Compensatory mutations, which ameliorate the cost of plasmid carriage,… read more here.
Keywords: fitness cost; plant rhizosphere; cost; compensatory mutations ... See more keywords
Fitness Cost of Sequential Selection with Deltamethrin in Aedes aegypti (Diptera: Culicidae)
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DOI: 10.1093/jme/tjac032
Abstract: Abstract In Mexico, Aedes aegypti (L.) is the primary dengue vector, chikungunya, and Zika viruses. The continued use of synthetic pyrethroids has led to the development of resistance in target populations, which has diminished the… read more here.
Keywords: aedes aegypti; selection deltamethrin; fitness cost; cost ... See more keywords
Fitness cost and compensation mechanism of sulfonamide resistance genes (sul1, sul2, and sul3) in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental microbiology"
DOI: 10.1111/1462-2920.15783
Abstract: The fitness cost of antibiotic resistance is a crucial factor to determine the evolutionary and transmission success of resistant bacteria. Exploring the fitness cost and compensation mechanism of ARGs in bacteria may effectively reduce the… read more here.
Keywords: sulfonamide resistance; cost; fitness cost; compensation mechanism ... See more keywords
A Screen for Antibiotic Resistance Determinants Reveals a Fitness Cost of the Flagellum in Pseudomonas aeruginosa
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DOI: 10.1128/jb.00682-19
Abstract: The cell envelopes of Gram-negative bacteria render them intrinsically resistant to many classes of antibiotics. We used insertion sequencing to identify genes whose disruption altered the fitness of a highly antibiotic-resistant pathogen, Pseudomonas aeruginosa, in… read more here.
Keywords: fitness cost; presence; fitness; vancomycin ... See more keywords
The fitness cost of mis-splicing is the main determinant of alternative splicing patterns
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DOI: 10.1186/s13059-017-1344-6
Abstract: BackgroundMost eukaryotic genes are subject to alternative splicing (AS), which may contribute to the production of protein variants or to the regulation of gene expression via nonsense-mediated messenger RNA (mRNA) decay (NMD). However, a fraction… read more here.
Keywords: expression; fitness cost; alternative splicing; gene expression ... See more keywords
Quantifying the fitness cost of HIV-1 drug resistance mutations through phylodynamics
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DOI: 10.1371/journal.ppat.1006895
Abstract: Drug resistant HIV is a major threat to the long-term efficacy of antiretroviral treatment. Around 10% of ART-naïve patients in Europe are infected with drug-resistant HIV type 1. Hence it is important to understand the… read more here.
Keywords: drug resistance; fitness cost; drug; resistance ... See more keywords
Large-Scale Analysis of Fitness Cost of tet(X4)-Positive Plasmids in Escherichia coli
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DOI: 10.3389/fcimb.2022.798802
Abstract: Tigecycline is one of important antimicrobial agents for the treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria. However, the emergence and prevalence of plasmid-mediated tigecycline resistance gene tet(X4) are threatening human and animal health.… read more here.
Keywords: analysis fitness; fitness cost; tet positive; positive plasmids ... See more keywords