Physiological, but not fitness, effects of two interacting haemoparasitic infections in a wild rodent.
Sign Up to like & getrecommendations! Published in 2018 at "International journal for parasitology"
DOI: 10.1016/j.ijpara.2017.11.006
Abstract: In contrast to the conditions in most laboratory studies, wild animals are routinely challenged by multiple infections simultaneously, and these infections can interact in complex ways. This means that the impact of a parasite on… read more here.
Keywords: effects two; physiological fitness; bartonella spp; fitness effects ... See more keywords
Fitness Effects of Mutations: An Assessment of PROVEAN Predictions Using Mutation Accumulation Data
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evac004
Abstract: Abstract Predicting fitness in natural populations is a major challenge in biology. It may be possible to leverage fast-accumulating genomic data sets to infer the fitness effects of mutant alleles, allowing evolutionary questions to be… read more here.
Keywords: fitness effects; biology; mutation accumulation; fitness ... See more keywords
Rapid Intraspecies Evolution of Fitness Effects of Yeast Genes
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evac061
Abstract: Abstract Organisms within species have numerous genetic and phenotypic variations. Growing evidences show intraspecies variation of mutant phenotypes may be more complicated than expected. Current studies on intraspecies variations of mutant phenotypes are limited to… read more here.
Keywords: strain specific; fitness effects; intraspecies variation; fitness effect ... See more keywords
Overdominant and partially dominant mutations drive clonal adaptation in diploid Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac061
Abstract: Identification of adaptive targets in experimental evolution typically relies on extensive replication and genetic reconstruction. An alternative approach is to directly assay all mutations in an evolved clone by generating pools of segregants that contain… read more here.
Keywords: adaptation; evolved clones; fitness effects; overdominant partially ... See more keywords
The Role of the Environment in Horizontal Gene Transfer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac220
Abstract: Abstract Gene-by-environment interactions play a crucial role in horizontal gene transfer by affecting how the transferred genes alter host fitness. However, how the environment modulates the fitness effect of transferred genes has not been tested… read more here.
Keywords: horizontal gene; environment; fitness effects; gene transfer ... See more keywords
Genes Vary Greatly in Their Propensity for Collateral Fitness Effects of Mutations
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad038
Abstract: Mutations can have deleterious fitness effects when they decrease protein specific activity or decrease active protein abundance. Mutations will also be deleterious when they cause misfolding or misinteractions that are toxic to the cell (i.e.,… read more here.
Keywords: vary greatly; genes vary; fitness effects; collateral fitness ... See more keywords
Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.08.11.503594
Abstract: Causal loss-of-function (LOF) variants for Mendelian and severe complex diseases are enriched in “mutation intolerant” genes. We show how such observations can be interpreted in light of a model of mutation-selection balance, and use the… read more here.
Keywords: loss function; fitness effects; evolutionary fitness; fitness ... See more keywords
Resolving Deleterious and Near-Neutral Effects Requires Different Pooled Fitness Assay Designs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Evolution"
DOI: 10.1101/2022.08.19.504558
Abstract: Pooled sequencing-based fitness assays are a powerful and widely used approach to quantifying fitness of thousands of genetic variants in parallel. Despite the throughput of such assays, they are prone to biases in fitness estimates,… read more here.
Keywords: pooled fitness; neutral effects; fitness effects; deleterious near ... See more keywords
Weak antagonistic fitness effects can maintain an inversion polymorphism.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular ecology"
DOI: 10.1111/mec.16963
Abstract: The study of chromosomal inversion polymorphisms has received much recent attention, particularly in cases where inversions have drastic effects on phenotypes and fitness (e.g. lethality of homozygotes). Less attention has been paid to the question… read more here.
Keywords: antagonistic fitness; polymorphism; inversion; fitness effects ... See more keywords
Predicting the Fitness Effects of Climate Change on Snowshoe Hares
Sign Up to like & getrecommendations! Published in 2017 at "Arctic"
DOI: 10.14430/arctic4691
Abstract: C CHANGE IS CONSIDERED ONE OF the greatest potential threats to global biodiversity (Thomas et al., 2004). Currently, it is altering the distribution and abundance of numerous species (Parmesan, 2006), causing numerical declines in populations… read more here.
Keywords: change snowshoe; fitness effects; change; predicting fitness ... See more keywords
Comparison of the Full Distribution of Fitness Effects of New Amino Acid Mutations Across Great Apes
Sign Up to like & getrecommendations! Published in 2019 at "Genetics"
DOI: 10.1534/genetics.119.302494
Abstract: Castellano et al. provide the first comparison of the full distribution of fitness effects (including deleterious, neutral but also beneficial mutations) in the great apes. The authors investigate which aspects of the full DFE are… read more here.
Keywords: great apes; fitness effects; across great; distribution fitness ... See more keywords