Evolutionary mechanisms studied through protein fitness landscapes.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2018.01.001
Abstract: Biology has, and continues to be, shaped by evolutionary mechanisms. Within the past decade, local fitness landscapes have become experimentally tractable and are providing new perspectives on evolutionary mechanisms. Powered by next-generation sequencing, the impacts… read more here.
Keywords: fitness landscapes; mechanisms studied; studied protein; biology ... See more keywords
Dynamic RNA Fitness Landscapes of a Group I Ribozyme during Changes to the Experimental Environment
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msab373
Abstract: Abstract Fitness landscapes of protein and RNA molecules can be studied experimentally using high-throughput techniques to measure the functional effects of numerous combinations of mutations. The rugged topography of these molecular fitness landscapes is important… read more here.
Keywords: group ribozyme; magnesium; fitness landscapes; topography ... See more keywords
On the role of sex differences for evolution in heterogeneous and changing fitness landscapes: insights from pygmy grasshoppers
Sign Up to like & getrecommendations! Published in 2018 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2017.0429
Abstract: Much research has been devoted to study evolution of local adaptations by natural selection, and to explore the roles of neutral processes and developmental plasticity for patterns of diversity among individuals, populations and species. Some… read more here.
Keywords: differences evolution; sex differences; sex; fitness landscapes ... See more keywords
Lexical Landscapes as large in silico data for examining advanced properties of fitness landscapes
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DOI: 10.1371/journal.pone.0220891
Abstract: In silico approaches have served a central role in the development of evolutionary theory for generations. This especially applies to the concept of the fitness landscape, one of the most important abstractions in evolutionary genetics,… read more here.
Keywords: data examining; large silico; lexical landscapes; silico data ... See more keywords
Local Fitness Landscapes Predict Yeast Evolutionary Dynamics in Directionally Changing Environments
Sign Up to like & getrecommendations! Published in 2017 at "Genetics"
DOI: 10.1534/genetics.117.300519
Abstract: The fitness landscape is a concept that is widely used for understanding and predicting evolutionary adaptation. The topography of the fitness landscape depends critically on the environment, with potentially far-reaching consequences for evolution under changing… read more here.
Keywords: topography; landscape; local fitness; fitness ... See more keywords