Sparse dictionary learning recovers pleiotropy from human cell fitness screens.
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DOI: 10.1016/j.cels.2021.12.005
Abstract: In high-throughput functional genomic screens, each gene product is commonly assumed to exhibit a singular biological function within a defined protein complex or pathway. In practice, a single gene perturbation may induce multiple cascading functional… read more here.
Keywords: fitness screens; gene perturbation; cell fitness; fitness ... See more keywords