Simultaneous determination of five alkaloids from Rauvolfia Vomitoria in rat plasma by LC-MS/MS: application to a comparative pharmacokinetic study in normal and Type 2 diabetic rats.
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DOI: 10.1002/jssc.202000914
Abstract: Rauvolfia vomitoria is widely distributed in the tropical regions of Africa and Asia, and has been used in traditional folk medicine in China. Indole alkaloids were found to be major bioactive components, while the effects… read more here.
Keywords: simultaneous determination; medicine; determination five; rauvolfia vomitoria ... See more keywords
Effect of CYP3A inducer/inhibitor on pharmacokinetics of five alkaloids in Evodiae Fructus.
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DOI: 10.1016/j.cbi.2020.109146
Abstract: Evodiae Fructus (EF), the dried nearly mature scented fruit of Tetradium ruticarpum (A.Juss.) T.G.Hartley, was typically used to treat headache, abdominal pain, hernias, and menorrhagia for thousands of years. It had been reported to be… read more here.
Keywords: inhibitor; cyp3a; evodiae fructus; five alkaloids ... See more keywords
Simultaneous Determination of Five Alkaloids by HPLC-MS/MS Combined With Micro-SPE in Rat Plasma and Its Application to Pharmacokinetics After Oral Administration of Lotus Leaf Extract
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DOI: 10.3389/fphar.2019.01252
Abstract: An environment-friendly and efficient method for simultaneous determination of five alkaloids (nunciferine, O-nornuciferin, liriodenine, armepavine, and pronuciferine) in rat plasma was established by HPLC-MS/MS associated with micro-solid phase extraction (micro-SPE). The plasma sample was pretreated… read more here.
Keywords: rat plasma; plasma; determination; five alkaloids ... See more keywords
Development and Validation of an UPLC-MS/MS Method for Pharmacokinetic Comparison of Five Alkaloids from JinQi Jiangtang Tablets and Its Monarch Drug Coptidis Rhizoma
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DOI: 10.3390/pharmaceutics10010004
Abstract: JinQi Jiangtang (JQJT) tablets, a Chinese patent medicine approved by the State Food and Drug Administration, are composed of Coptidis Rhizoma, Astragali Radix, and Lonicerae Japonicae Flos, and have a significant effect on diabetes. Coptidis… read more here.
Keywords: jinqi jiangtang; drug; five alkaloids; coptidis rhizoma ... See more keywords