Human Rotaviruses of Multiple Genotypes Acquire Conserved VP4 Mutations during Serial Passage
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DOI: 10.3390/v16060978
Abstract: Human rotaviruses exhibit limited tropism and replicate poorly in most cell lines. Attachment protein VP4 is a key rotavirus tropism determinant. Previous studies in which human rotaviruses were adapted to cultured cells identified mutations in… read more here.
Keywords: human rotaviruses; five genotypes; rotavirus; passage ... See more keywords