Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five‐Membered Thiolactone Ring Formation
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DOI: 10.1002/cbic.201700090
Abstract: Thiolactomycin (TLM) belongs to a class of rare and unique thiotetronate antibiotics that inhibit bacterial fatty acid synthesis. Although this group of natural product antibiotics was first discovered over 30 years ago, the study of… read more here.
Keywords: thiolactomycin; thiolactone ring; membered thiolactone; thiolactone ... See more keywords
Acyclic Nucleoside Phosphonates Containing 9‐Deazahypoxanthine and a Five‐Membered Heterocycle as Selective Inhibitors of Plasmodial 6‐Oxopurine Phosphoribosyltransferases
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DOI: 10.1002/cmdc.201700293
Abstract: Acyclic nucleoside phosphonates (ANPs) are an important class of therapeutic drugs that act as antiviral agents by inhibiting viral DNA polymerases and reverse transcriptases. ANPs containing a 6‐oxopurine unit instead of a 6‐aminopurine or pyrimidine… read more here.
Keywords: nucleoside phosphonates; membered heterocycle; five membered; deazahypoxanthine five ... See more keywords
Reversal of Stereoselectivity in Cycloadditions of Five‐Membered Cyclic Nitrones Derived from Hexoses
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DOI: 10.1002/ejoc.201601488
Abstract: Two five-membered cyclic nitrones derived from hexoses, a newly synthesized D-allo-configured nitrone and an already known D-talo-configured nitrone, have been examined in 1,3-dipolar cycloaddition reactions with vinyl acetate, allyl benzoate, methyl acrylate, acrylonitrile, and vinylene… read more here.
Keywords: cyclic nitrones; membered cyclic; derived hexoses; five membered ... See more keywords
The use of N-halosuccinimides for cyclization with the formation of five-membered heterocyclic compounds
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-020-02616-5
Abstract: The review summarizes the literature data for the period 2000–2017 on the most successful use of N-halosuccinimides in the preparative synthesis of five-membered heterocyclic compounds. The review is structured in accordance with the classification of… read more here.
Keywords: heterocyclic compounds; membered heterocyclic; compounds use; use halosuccinimides ... See more keywords
Synthesis and Transformation of Triterpenoids with a β-Ketonitrile Fragment in Five-Membered Ring A
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DOI: 10.1007/s10600-020-03233-6
Abstract: Triterpenoids with a β-ketonitrile group in five-membered ring A were synthesized via intramolecular oxonitrile cyclization of C-3 methyl esters of 1-cyano-substituted 2,3-seco-triterpene acids. The intramolecular cyclization to form the triterpene ketonitriles and subsequent reduction of… read more here.
Keywords: membered ring; synthesis transformation; transformation triterpenoids; triterpenoids ketonitrile ... See more keywords
Photolysis mechanism of sulfonamide moiety in five-membered sulfonamides: A DFT study.
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DOI: 10.1016/j.chemosphere.2018.01.041
Abstract: Quantum chemical calculations have been performed to investigate the photolysis mechanism of relatively susceptible sulfonamide moiety of five-membered sulfonamide (SA) antibiotics, such as sulfamethoxazole, sulfisoxazole, sulfamethizole, and sulfathiazole. The results show that the ·OH-mediated indirect… read more here.
Keywords: photolysis; photolysis mechanism; sulfonamide moiety; five membered ... See more keywords
Carbon nitride of five-membered rings with low optical bandgap for photoelectrochemical biosensing
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DOI: 10.1016/j.chempr.2021.06.010
Abstract: Summary As an analog of graphene, carbon nitrides have drawn increasing attention, ranging from artificial photosynthesis to synthetic organic chemistry. Notably, the most studied polymeric, C3N4, and other stoichiometric ones, such as C3N5, C4N3, and… read more here.
Keywords: photoelectrochemical biosensing; five membered; membered rings; carbon ... See more keywords
Synthesis, structure and catalytic activity of novel five-membered Pd(II) and Pt(II) metallaheterocycles based on 1,2-bis(3,5-dimethylisoxazol-4-yl-methylsulfanyl)ethane
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2018.07.026
Abstract: Abstract Novel palladium(II) and platinum(II) heterocycles were synthesized based 1,2-bis(3,5-dimethylisoxazol-4-ylmethylsulfanyl)ethane. According to X-ray Crystallographic data in molecule there are two bonds between divalent sulfur atoms and metal atom S-Pd-S to form a five-membered palladacycle in… read more here.
Keywords: dimethylisoxazol; bis dimethylisoxazol; methylsulfanyl ethane; dimethylisoxazol methylsulfanyl ... See more keywords
Enthalpy of formation calculations on five-membered azaborolidine derivatives
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DOI: 10.1016/j.molstruc.2020.128321
Abstract: Abstract The derivatives of azaborolidine are a class of 5-membered heterocyclic compounds containing a ring with nitrogen atoms and boron atoms. In this study, enthalpy of formation (H) of 5-membered boron-nitrogen heterocyclic species (BxNyHz) were… read more here.
Keywords: calculations five; enthalpy formation; formation; five membered ... See more keywords
Effects of Aromaticity and Connectivity on the Conductance of Five-Membered Rings
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DOI: 10.1021/acs.jpcc.7b00283
Abstract: Even though five-membered rings, for example, thiophene, are ubiquitous in organic and molecular electronics, as a class of molecules, they resist a simple interpretation. Generally containing four sp2-hybridized carbon atoms, the fifth position can be… read more here.
Keywords: membered rings; connectivity conductance; aromaticity connectivity; connectivity ... See more keywords
Synthesis and Antibacterial Activities of Different Five-Membered Heterocyclic Rings Incorporated with Pyridothienopyrimidine
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DOI: 10.1021/acsomega.0c00188
Abstract: Certain pyridothienopyrimidine derivatives exhibit antiatheroscleorotic, antibacterial, antiviral, antidepressant, antidiabetic, antihypertensive, anticancer, antihistaminic, antiallergic, anti-inflammatory, spasmolytic, analgesic, and neurotropic activities. 4-Hydrazino-7,9-dimethylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine (1) is a reported pyridothienopyrimidine derivative. In the current study, (1) has been reacted with… read more here.
Keywords: heterocyclic rings; synthesis antibacterial; membered heterocyclic; rings incorporated ... See more keywords