In vivo enrichment of genetically manipulated platelets for murine hemophilia B gene therapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29861
Abstract: Our previous studies have demonstrated that platelet‐targeted factor IX (FIX) gene therapy can introduce sustained platelet‐FIX expression in hemophilia B (FIXnull) mice. In this study, we aimed to enhance platelet‐FIX expression in FIXnull mice with… read more here.
Keywords: fix; gene therapy; mice; gene ... See more keywords
Major bleeding in a patient with warfarin-hypersensitive and factor IX propeptide variant, p.Ala37Thr, who was treated with a direct oral anti-Xa inhibitor
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3398-2
Abstract: Dear Editor, A variant of coagulation factor IX (FIX) is usually associated with hemophilia B, which causes severe bleeding, a prolonged activated partial prothrombin time (APTT) and markedly decreased FIX activity with a family history… read more here.
Keywords: warfarin; fix; anti; thrombosis ... See more keywords
FixMiner: Mining relevant fix patterns for automated program repair
Sign Up to like & getrecommendations! Published in 2020 at "Empirical Software Engineering"
DOI: 10.1007/s10664-019-09780-z
Abstract: Patching is a common activity in software development. It is generally performed on a source code base to address bugs or add new functionalities. In this context, given the recurrence of bugs across projects, the… read more here.
Keywords: fixminer; program repair; fix; fix patterns ... See more keywords
Mathematical model of thrombin generation and bleeding phenotype in Amish carriers of Factor IX:C deficiency vs. controls.
Sign Up to like & getrecommendations! Published in 2019 at "Thrombosis research"
DOI: 10.1016/j.thromres.2019.07.020
Abstract: INTRODUCTION Factor IX:C (FIX:C) levels vary in hemophilia B carriers even in pedigrees with a unifying genetic defect. Analyzing the balance between pro-and anticoagulants might increase our understanding of carriers' bleeding potential. AIM In this… read more here.
Keywords: fix; thrombin generation; mathematical model;
Factor IX stimulants in preclinical and early phase trials for hemophilia B treatment
Sign Up to like & getrecommendations! Published in 2024 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2024.2388565
Abstract: ABSTRACT Introduction Hemophilia B is a X-linked rare inherited bleeding disorder characterized by coagulation factor IX (FIX) deficiency. Therapy for hemophilia B is aimed at replacing the FIX deficiency by means of several plasma-derived or… read more here.
Keywords: treatment; preclinical early; factor stimulants; fix ... See more keywords
On the Use of Hidden Markov Model to Predict the Time to Fix Bugs
Sign Up to like & getrecommendations! Published in 2018 at "IEEE Transactions on Software Engineering"
DOI: 10.1109/tse.2017.2757480
Abstract: A significant amount of time is spent by software developers in investigating bug reports. It is useful to indicate when a bug report will be closed, since it would help software teams to prioritise their… read more here.
Keywords: hidden markov; fix; time; model ... See more keywords
Sustained high trough factor IX activity levels with continued use of rIX‐FP in adult and paediatric patients with haemophilia B
Sign Up to like & getrecommendations! Published in 2019 at "Haemophilia"
DOI: 10.1111/hae.13735
Abstract: Bleeding severity in haemophilia usually correlates with the lev‐ els of circulating clotting factor.1 Patients with mild (factor levels 6%‐40% of normal activity) or moderate haemophilia (1%‐5%) bleed infrequently, predominantly due to trauma or after… read more here.
Keywords: trough fix; fix; fix levels; steady state ... See more keywords
Erratum for Smercina et al., “To Fix or Not To Fix: Controls on Free-Living Nitrogen Fixation in the Rhizosphere”
Sign Up to like & getrecommendations! Published in 2019 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.02103-19
Abstract: Volume 85, no. 6, e02546-18, 2019, [https://doi.org/10.1128/AEM.02546-18][1]. Page 12, Acknowledgments: Line 4 should read as follows. “…(DOE BER Office of Science DE-SC0018409 and DE-FC02-07ER64494). Data presented in Table 1 were collected under the Facilities Integrating… read more here.
Keywords: erratum smercina; fix fix; fix; fix controls ... See more keywords
People Endorse Harsher Policies in Principle Than in Practice: Asymmetric Beliefs About Which Errors to Prevent Versus Fix
Sign Up to like & getrecommendations! Published in 2024 at "Psychological Science"
DOI: 10.1177/09567976241228504
Abstract: Countless policies are crafted with the intention of punishing all who do wrong or rewarding only those who do right. However, this requires accommodating certain mistakes: some who do not deserve to be punished might… read more here.
Keywords: harsher policies; practice; principle; people endorse ... See more keywords
A Single Intravenous Infusion of FLT180a Results in Factor IX Activity Levels of More Than 40% and Has the Potential to Provide a Functional Cure for Patients with Haemophilia B
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-118050
Abstract: Introduction: Haemophilia B is an X-linked disease caused by mutations of the F9 gene coding for Factor IX (FIX). It is classified as mild, moderate, or severe based on FIX level, which correlates to clinical… read more here.
Keywords: week; infusion; fix; flt180a ... See more keywords
Interaction between Collagen IV and Heparin-Binding Sites in the Activity, Distribution and Clearance of Factor IX(a)
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-211131
Abstract: Introduction: Factor IX (FIX) is unique among vitamin K-dependent coagulation factors in that a substantial portion is bound to extravascular sites. The extravascular compartment of the hemophilia B (HemB) mouse can bind ~3-fold more FIX… read more here.
Keywords: k132a; k5a; recovery; fix ... See more keywords