Efficacy and Safety of Anti-Xa-Guided Versus Fixed Dosing of Low Molecular Weight Heparin for Prevention of Venous Thromboembolism in Trauma Patients
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DOI: 10.1097/sla.0000000000005754
Abstract: Purpose: Trauma patients are at high risk of venous thromboembolism (VTE). We summarize the comparative efficacy and safety of anti-Xa-guided versus fixed dosing for low molecular weight heparin (LMWH) for the prevention of VTE in… read more here.
Keywords: fixed dosing; guided versus; anti guided; versus fixed ... See more keywords
Imatinib, sunitinib and pazopanib: From flat‐fixed dosing towards a pharmacokinetically guided personalized dose
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DOI: 10.1111/bcp.14185
Abstract: Tyrosine kinase inhibitors (TKIs) are anti‐cancer drugs that target tyrosine kinases, enzymes that are involved in multiple cellular processes. Currently, multiple oral TKIs have been introduced in the treatment of solid tumours, all administered in… read more here.
Keywords: imatinib sunitinib; sunitinib pazopanib; pazopanib flat; fixed dosing ... See more keywords
Fixed dosing of kukoamine B in sepsis patients: Results from population pharmacokinetic modelling and simulation.
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DOI: 10.1111/bcp.15342
Abstract: AIMS To assess the appropriateness of the bodyweight or fixed dosing regimen, population pharmacokinetic (PopPK) model of kukoamine B has been built in sepsis patients. METHODS Plasma Concentrations of kukoamine B and the covariates information… read more here.
Keywords: fixed dosing; model; dosing regimen; simulation ... See more keywords
Evaluation of dosing strategy for pembrolizumab for oncology indications
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DOI: 10.1186/s40425-017-0242-5
Abstract: BackgroundTraditionally, most monoclonal antibodies (mAbs) have been dosed based on body weight because of perceived contribution of body size in pharmacokinetic variability. The same approach was used in the initial pembrolizumab studies; however, following availability… read more here.
Keywords: range; weight; fixed dosing; cancer ... See more keywords