Immuno‐Isolation Strategy with Tacrolimus‐Loaded Nanofilm Promotes Stable Stem Cell‐Based Cartilage Regeneration
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202414567
Abstract: Bone marrow stem cells (BMSCs)‐engineered cartilage (BEC) shows promise for clinically repairing cartilage defects. However, when implanted in immunocompetent large animals, BEC becomes susceptible to ossification due to inflammatory infiltration. To address this, a nanofilm… read more here.
Keywords: stem cell; isolation strategy; cartilage; fk506 ... See more keywords
Efficiency encapsulation of FK506 with new dual self-assembly multi-hydrophobic-core nanoparticles for preventing keratoplasty rejection.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203242
Abstract: Nanoparticles self-assembled by amphiphilic co-polymers for loading hydrophobic molecules have been intensively investigated. However, their hydrophobic molecule-loading capacity is low due to the limitation of hydrophobic groups in these co-polymers. In this regard, new lysine… read more here.
Keywords: fk506; multi hydrophobic; hydrophobic core; core nanoparticles ... See more keywords
Local FK506 dose‐dependent study using a novel three‐dimensional organotypic assay
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26853
Abstract: Local administration of FK506, an FDA approved immunosuppressant with neuroregenerative properties, is a promising technique to achieve improved peripheral nerve regeneration while preventing the side effects associated with the systemic administration of this drug. Although… read more here.
Keywords: fk506; study; dose; peripheral nerve ... See more keywords
Local delivery of FK506 to injured peripheral nerve enhances axon regeneration after surgical nerve repair in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.05.058
Abstract: Administration of FK506, an FDA approved immunosuppressant, has been shown to enhance nerve regeneration following peripheral nerve injuries. However, the severe side effects of the systemically delivered FK506 has prevented clinicians from the routine use… read more here.
Keywords: fk506; delivery; regeneration; nerve ... See more keywords
FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.03.062
Abstract: The 12-kDa FK506-binding protein (FKBP12) is the target of the commonly used immunosuppressive drug FK506. The FKBP12-FK506 complex binds to calcineurin and inhibits its activity, leading to immunosuppression and preventing organ transplant rejection. Our recent… read more here.
Keywords: fkbp12 dimerization; fk506; aspergillus fumigatus; fk506 binding ... See more keywords
A novel FK506 loaded nanomicelles consisting of amino-terminated poly(ethylene glycol)-block-poly(D,L)-lactic acid and hydroxypropyl methylcellulose for ocular drug delivery.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.03.022
Abstract: FK506 (tacrolimus) is an effective immunosuppressant, but its poor water solubility and low bioavailability impose barriers to ocular drug delivery. The nanomicelles (NMs) formulations comprised of amino-terminated poly(ethylene glycol-block-poly(D,L)-lactic acid) (NH2-PEG-b-PLA) and hydroxypropyl methylcellulose (HPMC)… read more here.
Keywords: fk506; ocular drug; drug delivery; drug ... See more keywords
Delivery of FK506-loaded PLGA nanoparticles prolongs cardiac allograft survival.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118951
Abstract: In this study, FK506-loaded poly(lactide-co-glycolide) nanoparticles (PLGA-FK506-NPs) were developed using an O/W emulsion solvent evaporation method. The PLGA-FK506-NPs were observed to be monodispersed and spherical by transmission and scanning electron microscopy. The mean size and… read more here.
Keywords: fk506; allograft survival; plga fk506; fk506 nps ... See more keywords
FK506, an Immunosuppressive Drug, Induces Autophagy by Binding to the V-ATPase Catalytic Subunit A in Neuronal Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.6b00638
Abstract: The drug FK506 (tacrolimus, fujimycin) exerts its immunosuppressive effects by regulating the nuclear factor of the activated T-cell (NFAT) family of transcription factors. However, FK506 also exhibits neuroprotective effects, but its direct target proteins that… read more here.
Keywords: fk506; catalytic subunit; target; drug ... See more keywords
Targeting ARNT to attenuate renal fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Nephrology"
DOI: 10.1038/s41581-018-0038-y
Abstract: © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature reviews | Nephrology Fibrosis is an important driver of end-stage organ failure and death in a variety of chronic diseases, including chronic… read more here.
Keywords: fk506; transcription; fibrosis; alk3 transcription ... See more keywords
Innovative nanostructured lipid-particles of apocynin and clove oil tagged with Chitin oligosaccharide for amelioration of tacrolimus-induced nephrotoxicity
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-13978-1
Abstract: Tacrolimus (FK506) is a potent immunosuppressive agent widely employed to prevent allogeneic rejection in transplant recipients. However, its nephrotoxic effects pose significant limitations to long-term therapeutic use. To address this challenge, the present study aims… read more here.
Keywords: tacrolimus; fk506; nanostructured lipid; induced nephrotoxicity ... See more keywords
Isoglycyrrhizinate Magnesium Enhances Hepatoprotective Effect of FK506 on Ischemia-Reperfusion Injury Through HMGB1 Inhibition in a Rat Model of Liver Transplantation
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation"
DOI: 10.1097/tp.0000000000001941
Abstract: Background Ischemia-reperfusion injury after liver transplantation (LT) impairs graft function and affects prognosis of recipients. Isoglycyrrhizinate magnesium (Iso) is a hepatoprotective drug usually used after liver injury. In this study, we intended to explore whether… read more here.
Keywords: fk506; hepatoprotective effect; effect fk506; effect ... See more keywords