Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity.
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DOI: 10.1021/acs.jnatprod.9b00144
Abstract: A reduction in the strong immunosuppressive activity of FK506 (1) is essential for developing this compound as an antifungal agent. Seven new FK506 analogues modified at both the FK506-binding protein 12- and the calcineurin-binding regions… read more here.
Keywords: biosynthesis nonimmunosuppressive; fk506 analogues; antifungal activity; activity ... See more keywords