A twist in the ABC: regulation of ABC transporter trafficking and transport by FK506‐binding proteins
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13983
Abstract: Post‐transcriptional regulation of ATP‐binding cassette (ABC) proteins has been so far shown to encompass protein phosphorylation, maturation, and ubiquitination. Yet, recent accumulating evidence implicates FK506‐binding proteins (FKBPs), a type of peptidylprolyl cis–trans isomerase (PPIase) proteins,… read more here.
Keywords: binding proteins; abc transporter; abc; fk506 binding ... See more keywords
FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.03.062
Abstract: The 12-kDa FK506-binding protein (FKBP12) is the target of the commonly used immunosuppressive drug FK506. The FKBP12-FK506 complex binds to calcineurin and inhibits its activity, leading to immunosuppression and preventing organ transplant rejection. Our recent… read more here.
Keywords: fkbp12 dimerization; fk506; aspergillus fumigatus; fk506 binding ... See more keywords
Conformational Entropy of FK506 Binding to FKBP12 Determined by Nuclear Magnetic Resonance Relaxation and Molecular Dynamics Simulations.
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DOI: 10.1021/acs.biochem.7b01256
Abstract: FKBP12 (FK506 binding protein 12 kDa) is an important drug target. Nuclear magnetic resonance (NMR) order parameters, describing amplitudes of motion on the pico- to nanosecond time scale, can provide estimates of changes in conformational… read more here.
Keywords: fk506 binding; conformational entropy; fkbp12; nuclear magnetic ... See more keywords
Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins.
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DOI: 10.1021/acs.jmedchem.8b00137
Abstract: FK506-binding proteins (FKBPs) are evolutionarily conserved proteins that display peptidyl-prolyl isomerase activities and act as coreceptors for immunosuppressants. Microbial macrophage-infectivity-potentiator (Mip)-type FKBPs can enhance infectivity. However, developing druglike ligands for FKBPs or Mips has proven… read more here.
Keywords: binding proteins; chemogenomic profiling; fk506 binding; profiling human ... See more keywords
Publisher's Note: Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding. J. Cell Sci. doi: 10.1242/jcs.204461.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of cell science"
DOI: 10.1242/jcs.211243
Abstract: This Publisher's Note relates to the article ‘Association of FK506 binding proteins with RyR channels – effect of CLIC2 binding on sub-conductance opening and FKBP binding’ by Spencer J. Richardson, Gregory A. Steele, Esther M.… read more here.
Keywords: binding proteins; ryr channels; proteins ryr; publisher note ... See more keywords
Genome-wide characterization of FK506-binding proteins, parvulins and phospho-tyrosyl phosphatase activators in wheat and their regulation by heat stress
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1053524
Abstract: Peptidyl-prolyl cis-trans isomerases (PPIases) are ubiquitous proteins which are essential for cis-trans isomerisation of peptide bonds preceding the proline residue. PPIases are categorized into four sub-families viz., cyclophilins, FK506-binding proteins (FKBPs), parvulins and protein phosphatase… read more here.
Keywords: heat stress; genome wide; fk506 binding; phosphatase activators ... See more keywords
FK506-Binding Protein like (FKBPL) Has an Important Role in Heart Failure with Preserved Ejection Fraction Pathogenesis with Potential Diagnostic Utility
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020395
Abstract: Heart failure (HF) is the leading cause of hospitalisations worldwide, with only 35% of patients surviving the first 5 years after diagnosis. The pathogenesis of HF with preserved ejection fraction (HFpEF) is still unclear, impeding… read more here.
Keywords: heart failure; preserved ejection; hfpef; fk506 binding ... See more keywords