A twist in the ABC: regulation of ABC transporter trafficking and transport by FK506‐binding proteins
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13983
Abstract: Post‐transcriptional regulation of ATP‐binding cassette (ABC) proteins has been so far shown to encompass protein phosphorylation, maturation, and ubiquitination. Yet, recent accumulating evidence implicates FK506‐binding proteins (FKBPs), a type of peptidylprolyl cis–trans isomerase (PPIase) proteins,… read more here.
Keywords: binding proteins; abc transporter; abc; fk506 binding ... See more keywords
FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.03.062
Abstract: The 12-kDa FK506-binding protein (FKBP12) is the target of the commonly used immunosuppressive drug FK506. The FKBP12-FK506 complex binds to calcineurin and inhibits its activity, leading to immunosuppression and preventing organ transplant rejection. Our recent… read more here.
Keywords: fkbp12 dimerization; fk506; aspergillus fumigatus; fk506 binding ... See more keywords
Conformational Entropy of FK506 Binding to FKBP12 Determined by Nuclear Magnetic Resonance Relaxation and Molecular Dynamics Simulations.
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DOI: 10.1021/acs.biochem.7b01256
Abstract: FKBP12 (FK506 binding protein 12 kDa) is an important drug target. Nuclear magnetic resonance (NMR) order parameters, describing amplitudes of motion on the pico- to nanosecond time scale, can provide estimates of changes in conformational… read more here.
Keywords: fk506 binding; conformational entropy; fkbp12; nuclear magnetic ... See more keywords
Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00137
Abstract: FK506-binding proteins (FKBPs) are evolutionarily conserved proteins that display peptidyl-prolyl isomerase activities and act as coreceptors for immunosuppressants. Microbial macrophage-infectivity-potentiator (Mip)-type FKBPs can enhance infectivity. However, developing druglike ligands for FKBPs or Mips has proven… read more here.
Keywords: binding proteins; chemogenomic profiling; fk506 binding; profiling human ... See more keywords
Publisher's Note: Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding. J. Cell Sci. doi: 10.1242/jcs.204461.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of cell science"
DOI: 10.1242/jcs.211243
Abstract: This Publisher's Note relates to the article ‘Association of FK506 binding proteins with RyR channels – effect of CLIC2 binding on sub-conductance opening and FKBP binding’ by Spencer J. Richardson, Gregory A. Steele, Esther M.… read more here.
Keywords: binding proteins; ryr channels; proteins ryr; publisher note ... See more keywords
Genome-wide characterization of FK506-binding proteins, parvulins and phospho-tyrosyl phosphatase activators in wheat and their regulation by heat stress
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1053524
Abstract: Peptidyl-prolyl cis-trans isomerases (PPIases) are ubiquitous proteins which are essential for cis-trans isomerisation of peptide bonds preceding the proline residue. PPIases are categorized into four sub-families viz., cyclophilins, FK506-binding proteins (FKBPs), parvulins and protein phosphatase… read more here.
Keywords: heat stress; genome wide; fk506 binding; phosphatase activators ... See more keywords
FK506-Binding Protein like (FKBPL) Has an Important Role in Heart Failure with Preserved Ejection Fraction Pathogenesis with Potential Diagnostic Utility
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020395
Abstract: Heart failure (HF) is the leading cause of hospitalisations worldwide, with only 35% of patients surviving the first 5 years after diagnosis. The pathogenesis of HF with preserved ejection fraction (HFpEF) is still unclear, impeding… read more here.
Keywords: heart failure; preserved ejection; hfpef; fk506 binding ... See more keywords
Genome-Wide Identification and Bioinformatics Analysis of the FK506 Binding Protein Family in Rice
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DOI: 10.3390/genes15070902
Abstract: The FK506 Binding Protein (FKBP), ubiquitously present across diverse species, is characterized by its evolutionarily conserved FK506 binding domain (FKBd). In plants, evidence suggests that this gene family plays integral roles in regulating growth, development,… read more here.
Keywords: family; rice; fk506 binding; identification ... See more keywords