Articles with "fk866" as a keyword



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FK866 alleviates cerebral pyroptosis and inflammation mediated by Drp1 in a rat cardiopulmonary resuscitation model.

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Published in 2020 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2020.107032

Abstract: OBJECTIVES Dynamin-related protein 1 (Drp1) mediates mitochondrial fission and triggers NLRP3 inflammasome activation. FK866 (a NAMPT inhibitor) exerts a neuroprotective effect in ischemia/reperfusion injury through the suppression of mitochondrial dysfunction. We explored the effects of… read more here.

Keywords: pyroptosis inflammation; inflammation mediated; fk866; mediated drp1 ... See more keywords
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FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy

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Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-02318-7

Abstract: FK866 exhibits a protective effect on D-galactosamine (GaIN)/lipopolysaccharide (LPS) and concanavalin A (ConA)-induced acute liver failure (ALF), but the mechanism by which FK866 affords this benefit has not yet been elucidated. Autophagy has a protective… read more here.

Keywords: jnk; jun terminal; terminal kinase; fk866 ... See more keywords

Association of ABC Transporter With Resistance to FK866, a NAMPT Inhibitor, in Human Colorectal Cancer Cells

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Published in 2019 at "AntiCancer Research"

DOI: 10.21873/anticanres.13859

Abstract: Background/Aim: Nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in the NAD+ biosynthetic pathway, is a drug target of potent anticancer candidates, including FK866 and other reported NAMPT inhibitors. However, it is known that NAMPT point-mutations render… read more here.

Keywords: parental hct116; resistance; fk866; nampt inhibitor ... See more keywords