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Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107032
Abstract: OBJECTIVES Dynamin-related protein 1 (Drp1) mediates mitochondrial fission and triggers NLRP3 inflammasome activation. FK866 (a NAMPT inhibitor) exerts a neuroprotective effect in ischemia/reperfusion injury through the suppression of mitochondrial dysfunction. We explored the effects of…
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Keywords:
pyroptosis inflammation;
inflammation mediated;
fk866;
mediated drp1 ... See more keywords
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02318-7
Abstract: FK866 exhibits a protective effect on D-galactosamine (GaIN)/lipopolysaccharide (LPS) and concanavalin A (ConA)-induced acute liver failure (ALF), but the mechanism by which FK866 affords this benefit has not yet been elucidated. Autophagy has a protective…
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Keywords:
jnk;
jun terminal;
terminal kinase;
fk866 ... See more keywords
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Published in 2019 at "AntiCancer Research"
DOI: 10.21873/anticanres.13859
Abstract: Background/Aim: Nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in the NAD+ biosynthetic pathway, is a drug target of potent anticancer candidates, including FK866 and other reported NAMPT inhibitors. However, it is known that NAMPT point-mutations render…
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Keywords:
parental hct116;
resistance;
fk866;
nampt inhibitor ... See more keywords