LAUSR

FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.

Sign Up to like & get
recommendations!
0 Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.03.062

Abstract: The 12-kDa FK506-binding protein (FKBP12) is the target of the commonly used immunosuppressive drug FK506. The FKBP12-FK506 complex binds to calcineurin and inhibits its activity, leading to immunosuppression and preventing organ transplant rejection. Our recent… read more here.

Keywords: fkbp12 dimerization; fk506; aspergillus fumigatus; fk506 binding ... See more keywords