Andrographolide ameliorates sepsis-induced acute liver injury by attenuating endoplasmic reticulum stress through the FKBP1A-mediated NOTCH1/AK2 pathway
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DOI: 10.1007/s10565-025-10007-9
Abstract: Andrographolide (AP) has been shown to possess anti-inflammatory activities. In this study, the impact of AP in sepsis-induced acute liver injury (ALI) and the molecules involved were dissected. FKBP1A was predicted to be the sole… read more here.
Keywords: induced acute; acute liver; notch1 ak2; fkbp1a ... See more keywords
The Prognostic Significance of FKBP1A and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma
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DOI: 10.3390/ijms232112797
Abstract: Liver hepatocellular carcinoma (LIHC) remains a global health challenge with poor prognosis and high mortality. FKBP1A was first discovered as a receptor for the immunosuppressant drug FK506 in immune cells and is critical for various… read more here.
Keywords: infiltration; fkbp1a expression; expression; lihc ... See more keywords
Upregulated FKBP1A Suppresses Glioblastoma Cell Growth via Apoptosis Pathway
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DOI: 10.3390/ijms232314935
Abstract: Glioblastoma (GBM), the most deadly primary brain tumor, presents a major medical difficulty. The need for better therapeutic targets in GBM is therefore urgent. A growing body of evidence suggests that the gene FKBP1A plays… read more here.
Keywords: cell; apoptosis; upregulated fkbp1a; gbm ... See more keywords