FKBP5 polymorphisms and hypothalamic-pituitary-adrenal axis negative feedback in major depression and obsessive-compulsive disorder.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2018.08.003
Abstract: Major depressive disorder (MDD) and obsessive-compulsive disorder (OCD) have both been linked to abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. Polymorphisms in the genes involved in HPA axis activity, such as FKBP5, and their interactions with… read more here.
Keywords: axis; negative feedback; disorder; axis negative ... See more keywords
Sequencing the serotonergic neuron translatome reveals a new role for Fkbp5 in stress
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-0750-4
Abstract: Serotonin is a key mediator of stress, anxiety, and depression, and novel therapeutic targets within serotonin neurons are needed to combat these disorders. To determine how stress alters the translational profile of serotonin neurons, we… read more here.
Keywords: sequencing serotonergic; neuron translatome; serotonergic neuron; stress ... See more keywords
KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-021-04416-z
Abstract: Despite the association between cognitive impairment and delirium, little is known about whether genetic differences that confer cognitive resilience also confer resistance to delirium. To investigate whether older adults without postoperative delirium, compared with those… read more here.
Keywords: fkbp5; kibra mtnr1b; postoperative delirium; incident delirium ... See more keywords
Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-98032-6
Abstract: The FKBP5 gene is known to have an important role in alcohol use disorder (AUD) in response to stress and has been reported to affect stress responses by interacting with childhood trauma. This study investigated… read more here.
Keywords: resilience; rs1360780; trait resilience; alcohol use ... See more keywords
FKBP5/FKBP51 on weight watch: central FKBP5 links regulatory WIPI protein networks to autophagy and metabolic control
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2063006
Abstract: ABSTRACT Stress and changes in energy stores are perceived by hormone- and nutrient-sensing nuclei of the hypothalamus, which orchestrate an adaptive physiological body response to maintain homeostasis. Macroautophagy/autophagy is a fundamental lysosomal degradation system contributing… read more here.
Keywords: fkbp5 fkbp51; kinase; fkbp5; protein ... See more keywords
Circular noncoding RNA circ_0007865, serves as a competing endogenous RNA, targeting the miR-214-3p/FKBP5 axis to regulate oxygen-glucose deprivation-induced injury in brain microvascular endothelial cells.
Sign Up to like & getrecommendations! Published in 2022 at "Neuroreport"
DOI: 10.1097/wnr.0000000000001751
Abstract: BACKGROUND Ischemic stroke (IS) is a major cause of permanent morbidity and lifelong disability worldwide. Circular RNA (circRNA) circ_0007865 has been reported to be upregulated in acute ischemic stroke (AIS) patients. Also, AIS patients exhibited… read more here.
Keywords: mir 214; cell; circ 0007865; rna ... See more keywords
Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1101/2022.09.06.22279641
Abstract: High myopia (HM) is one of the leading causes of visual impairment and blindness worldwide. Here, we report a whole-exome sequencing (WES) study in 9,613 HM cases and 9,606 controls of Han Chinese ancestry to… read more here.
Keywords: ancestry; low frequency; high myopia; frequency variant ... See more keywords
Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Circulation research"
DOI: 10.1161/circresaha.122.322213
Abstract: BACKGROUND Atrial fibrillation (AF), the most common arrhythmia, is associated with the downregulation of FKBP5 (encoding FKBP5 [FK506 binding protein 5]). However, the function of FKBP5 in the heart remains unknown. Here, we elucidate the… read more here.
Keywords: cardiomyocyte; factor; fkbp5; mice ... See more keywords
The association of FKBP5 polymorphisms with the severity of depressive disorder in patients with methamphetamine use disorders
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2023.1147060
Abstract: Background Co-occurring depressive disorder (DD) in patients of methamphetamine use disorder (MAUD) impacts the diagnosis, treatment, and prognosis of the disease. Although FKBP5 has been associated with a variety of psychiatric disorders, whether FKBP5 influences… read more here.
Keywords: disorder patients; patients methamphetamine; fkbp5; methamphetamine use ... See more keywords
The Interactive Effect of Genetic and Epigenetic Variations in FKBP5 and ApoE Genes on Anxiety and Brain EEG Parameters
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13020164
Abstract: FKBP51 is a key stress-responsive regulator of the hypothalamic–pituitary–adrenal axis. To elucidate the contribution of rs1360780 FKBP5 C/T alleles to aging and longevity, we genotyped FKBP5 in a cohort of 800 non-demented and Alzheimer’s disease… read more here.
Keywords: state; effect; fkbp5 apoe; brain ... See more keywords