FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13030
Abstract: The growth of prostate cancer is dependent on the androgen receptor (AR), which serves as a ligand-specific transcription factor. Although two immunophilins, FKBP51 and FKBP52, are known to regulate AR activity, the precise mechanism remains… read more here.
Keywords: cancer; androgen receptor; fkbp51 fkbp52; prostate cancer ... See more keywords
Structure and function of the TPR-domain immunophilins FKBP51 and FKBP52 in normal physiology and disease.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30406
Abstract: Coordinated cochaperone interactions with Hsp90 and associated client proteins are crucial for a multitude of signaling pathways in normal physiology, as well as in disease settings. Research on the molecular mechanisms regulated by the Hsp90… read more here.
Keywords: fkbp51 fkbp52; disease; domain immunophilins; physiology ... See more keywords