Tricyclic antidepressants target FKBP51 SUMOylation to restore glucocorticoid receptor activity
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-022-01491-0
Abstract: FKBP51 is an important inhibitor of the glucocorticoid receptor (GR) signaling. High FKBP51 levels are associated to stress-related disorders, which are linked to GR resistance. SUMO conjugation to FKBP51 is necessary for FKBP51’s inhibitory action… read more here.
Keywords: glucocorticoid receptor; sumoylation; activity; tricyclic antidepressants ... See more keywords