Presence of L701 M mutation in the FKS1 gene of echinocandin-susceptible Candida krusei isolates.
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2018.07.005
Abstract: Resistance of Candida krusei isolates to echinocandins, the recommended drugs to treat candidemia, has been associated with mutations in hot spot (HS) regions of the FKS1 gene or L701 M mutation in a region between HS1… read more here.
Keywords: candida krusei; l701 mutation; fks1; mutation ... See more keywords
Effect of Conformational Variability on the Drug Resistance of Candida auris ERG11p and FKS1
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.3c08134
Abstract: Candida auris infection has been recognized as an urgent threat to antifungal drug resistance, and the Eagle effect of C. auris FKS1 (1,3-β-d-glucan synthase) wild-type isolates has also been noted. The Eagle effect, namely, where… read more here.
Keywords: resistance; effect; conformational variability; drug ... See more keywords