Extension and refinement of the recognition motif for Toll‐like receptor 5 activation by flagellin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3vma0118-035r
Abstract: TLRs sense conserved and essential molecular components of microbes that invade multicellular organisms. The wide range of TLR agonists, differing in size and shape, is recognized either through a single or a pair of binding… read more here.
Keywords: recognition; binding sites; receptor; flagellin ... See more keywords
Genomic and Transcriptomic Diversification of Flagellin Genes Provides Insight into Environmental Adaptation and Phylogeographic Characteristics in Aeromonas hydrophila
Sign Up to like & getrecommendations! Published in 2024 at "Microbial Ecology"
DOI: 10.1007/s00248-024-02373-4
Abstract: Aeromonas hydrophila is an opportunistic motile pathogen with a broad host range, infecting both terrestrial and aquatic animals. Environmental and geographical conditions exert selective pressure on both geno- and phenotypes of pathogens. Flagellin, directly exposed… read more here.
Keywords: flab; aeromonas hydrophila; flaa flab; flagellin ... See more keywords
F18+Escherichia coli flagellin expression in Salmonella has immunoadjuvant effects in a ghost vaccine candidate containing E. coli Stx2eB, FedF and FedA against porcine edema disease.
Sign Up to like & getrecommendations! Published in 2018 at "Comparative immunology, microbiology and infectious diseases"
DOI: 10.1016/j.cimid.2018.08.003
Abstract: Flagellin, a major structural component of bacteria flagella, is responsible for facilitating motility and invading host cells. The binding capacity of flagellin to toll-like receptor 5 (TLR5) and its trigger action for innate immunity make… read more here.
Keywords: candidate; vaccine candidate; ghost vaccine; expression ... See more keywords
Effect of flagellin on inhibition of infectious mechanisms by activating opsonization and salmonella flagellum disruption.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2020.104057
Abstract: Some serovars of salmonella cause huge global diseases such as enteric fever and invasive non typhoidal Salmonella disease. Flagellin as a key antigenic component of salmonella, can induce humoral and cellular immunity responses. In this… read more here.
Keywords: salmonella; inhibition; flagellum; motility ... See more keywords
Recombinant flagellins with deletions in domains D1, D2, and D3: Characterization as novel immunoadjuvants.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.12.009
Abstract: Bacterial flagellin activates the innate immune system and ultimately the adaptive immune system through a Toll-like receptor 5 (TLR5)-dependent signaling mechanism. Given that TLR5 is widely distributed in epithelia, flagellin is currently being developed as… read more here.
Keywords: flic 174; flagellin; tlr5 dependent; recombinant flagellins ... See more keywords
SUMO conjugation to the pattern recognition receptor FLS2 triggers intracellular signalling in plant innate immunity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07696-8
Abstract: Detection of conserved microbial patterns by host cell surface pattern recognition receptors (PRRs) activates innate immunity. The FLAGELLIN-SENSITIVE 2 (FLS2) receptor perceives bacterial flagellin and recruits another PRR, BAK1 and the cytoplasmic-kinase BIK1 to form… read more here.
Keywords: pattern recognition; immunity; fls2; innate immunity ... See more keywords
Reprogramming of flagellin receptor responses with surrogate ligands
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-54271-5
Abstract: Receptor kinase (RK) families process information from small molecules, short peptides, or glycan ligands to regulate core cellular pathways in plants. To date, whether individual plant RKs are capable of processing signals from distinct types… read more here.
Keywords: receptor; surrogate ligands; flagellin; reprogramming flagellin ... See more keywords
Second-generation Flagellin-rPAc Fusion Protein, KFD2-rPAc, Shows High Protective Efficacy against Dental Caries with Low Potential Side Effects
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10247-8
Abstract: Dental caries is one of the most common global chronic diseases affecting all ages of the population; thus a vaccine against caries is urgently needed. Our previous studies demonstrated that a fusion protein, KF-rPAc, in… read more here.
Keywords: kfd2 rpac; fusion protein; flagellin;
Inserting Omp22 into the flagellin protein, replacing its hypervariable region, results in stronger protection against lethal Acinetobacter baumannii infection
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-79013-x
Abstract: Acinetobacter baumannii, a common nosocomial pathogen, is known for its rapid acquisition of antimicrobial resistance, underscoring the urgent need to develop an effective vaccine against this pathogen. Outer membrane protein 22 (Omp22) regulates the biogenesis… read more here.
Keywords: acinetobacter baumannii; baumannii; flagellin; protein ... See more keywords
Enhanced TLR5-denpendent migration and activation of antigen-loaded airway dendritic cells by flagellin.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiad030
Abstract: Toll-like receptor 5 (TLR5) agonist flagellin is an effective mucosal adjuvant via intranasal (i.n.) administration. Previous studies demonstrated that the mucosal adjuvanticity of flagellin depends on TLR5 signaling of airway epithelial cells. Since dendritic cells… read more here.
Keywords: antigen loaded; enhanced tlr5; activation; flagellin enhanced ... See more keywords
Flagellin phase‐dependent swimming on epithelial cell surfaces contributes to productive Salmonella gut colonisation
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Microbiology"
DOI: 10.1111/cmi.12739
Abstract: The flagellum is a sophisticated nanomachine and an important virulence factor of many pathogenic bacteria. Flagellar motility enables directed movements towards host cells in a chemotactic process, and near‐surface swimming on cell surfaces is crucial… read more here.
Keywords: salmonella; cell surfaces; host cell; cell ... See more keywords