Structure, function and druggability of the African trypanosome flagellum
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30778
Abstract: African trypanosomes are early branching protists that cause human and animal diseases, termed trypanosomiases. They have been under intensive study for more than 100 years and have contributed significantly to our understanding of eukaryotic biology.… read more here.
Keywords: function; structure function; flagellum; druggability african ... See more keywords
Ultrastructural aspects of spermatogenesis in Calyptogena pacifica Dall 1891 (Vesicomyidae; Bivalvia)
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Morphology"
DOI: 10.1002/jmor.21292
Abstract: The process of spermatogenesis and spermatozoon morphology was characterized from a deep‐sea bivalve, Calyptogena pacifica (Vesicomyidae, Pliocardiinae), a member of the superfamily Glossoidea, using light and electron microscopy. Spermatogenesis in C. pacifica is generally similar… read more here.
Keywords: vesicomyidae; pacifica; proacrosomal vesicles; calyptogena pacifica ... See more keywords
Flagellum tapering and midpiece volume in songbird spermatozoa
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Morphology"
DOI: 10.1002/jmor.21524
Abstract: In contrast to numerous studies on spermatozoa length, relatively little work focuses on the width of spermatozoa, and particularly the width of the midpiece and flagellum. In flagellated spermatozoa, the flagellum provides forward thrust while… read more here.
Keywords: midpiece length; volume; flagellum; length ... See more keywords
Bee Parasites: Don’t Lose Your Flagellum
Sign Up to like & getrecommendations! Published in 2019 at "Current Biology"
DOI: 10.1016/j.cub.2019.08.034
Abstract: Bees can protect themselves from infection by accumulating specific nectars in the honey crop. A new study shows that as parasites pass through the crop, their flagellum is thereby removed, which prevents host infection. read more here.
Keywords: lose flagellum; parasites lose; bee parasites; biology ... See more keywords
Effect of flagellin on inhibition of infectious mechanisms by activating opsonization and salmonella flagellum disruption.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2020.104057
Abstract: Some serovars of salmonella cause huge global diseases such as enteric fever and invasive non typhoidal Salmonella disease. Flagellin as a key antigenic component of salmonella, can induce humoral and cellular immunity responses. In this… read more here.
Keywords: salmonella; inhibition; flagellum; motility ... See more keywords
Numerical exploration on buckling instability for directional control in flagellar propulsion.
Sign Up to like & getrecommendations! Published in 2019 at "Soft matter"
DOI: 10.1039/c9sm01843c
Abstract: We report a numerical method to control the swimming direction by exploiting buckling instability in uniflagellar bacteria and bio-inspired soft robots. Our model system is comprised of a spherical rigid head and a helical elastic… read more here.
Keywords: system; control; angular velocity; buckling instability ... See more keywords
FAP20 is required for flagellum assembly in Trypanosoma brucei
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e23-12-0497
Abstract: Trypanosoma brucei is a human and animal pathogen that depends on flagellar motility for transmission and infection. The trypanosome flagellum is built around a canonical “9+2” axoneme, containing nine doublet microtubules (DMTs) surrounding two singlet… read more here.
Keywords: flagellum assembly; fap20; flagellum; trypanosoma brucei ... See more keywords
Diversity in new flagellum tip attachment in bloodstream form African trypanosomes
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Microbiology"
DOI: 10.1111/mmi.14979
Abstract: The closely related parasites Trypanosoma brucei, T. congolense, and T. vivax cause neglected tropical diseases collectively known as African Trypanosomiasis. A characteristic feature of bloodstream form T. brucei is the flagellum that is laterally attached… read more here.
Keywords: tip attachment; bloodstream form; flagellum; new flagellum ... See more keywords
How the flagellum knows when to stop.
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.356.6334.149-r
Abstract: Size Control The bacterial flagellum is important in bacterial pathogenesis and biofilm formation. It is a rotary nanomotor that allows bacteria to propel themselves through liquids and across surfaces. Researchers interested in nanoscale robotics use… read more here.
Keywords: science; flagellum knows; flagellum; knows stop ... See more keywords
Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms.
Sign Up to like & getrecommendations! Published in 2025 at "Science"
DOI: 10.1126/science.adr3314
Abstract: The flagellum of Trypanosoma brucei drives the parasite's characteristic screw-like motion and is essential for its replication, transmission, and pathogenesis. However, the molecular details of this process remain unclear. Here, we present high-resolution (up to… read more here.
Keywords: flagellum assembly; motility; assembly motility; trypanosome doublet ... See more keywords
The kinetoplastid-specific phosphatase KPP1 attenuates PLK activity to facilitate flagellum inheritance in Trypanosoma brucei
Sign Up to like & getrecommendations! Published in 2021 at "Science Signaling"
DOI: 10.1126/scisignal.abc6435
Abstract: Flagellum inheritance in trypanosomes requires strategically timed suppression of Polo-like kinase activity. Passing the flagellum in trypanosomes The single flagellum of the unicellular parasite Trypanosoma brucei is critical for virulence, and Polo-like kinase (TbPLK) is… read more here.
Keywords: flagellum inheritance; inheritance; activity; flagellum ... See more keywords