Ultra-high dose rate electron beams and the FLASH effect: from preclinical evidence to a new radiotherapy paradigm.
Sign Up to like & getrecommendations! Published in 2022 at "Medical physics"
DOI: 10.1002/mp.15442
Abstract: In their seminal paper from 2014, Fauvadon et al. coined the term FLASH irradiation to describe ultra-high-dose-rate irradiation with dose rates greater than 40 Gy/s, which results in delivery times of fractions of a second. The… read more here.
Keywords: ultra high; flash effect; dose rate; dose ... See more keywords
A quantitative FLASH effectiveness model to reveal potentials and pitfalls of high dose rate proton therapy
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DOI: 10.1002/mp.15459
Abstract: Abstract Purpose In ultrahigh dose rate radiotherapy, the FLASH effect can lead to substantially reduced healthy tissue damage without affecting tumor control. Although many studies show promising results, the underlying biological mechanisms and the relevant… read more here.
Keywords: flash effect; dose rate; flash; proton therapy ... See more keywords
The minimal FLASH sparing effect needed to compensate the increase of radiobiological damage due to hypofractionation for late‐reacting tissues
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DOI: 10.1002/mp.15911
Abstract: Abstract Purpose Normal tissue (NT) sparing by ultra‐high dose rate (UHDR) irradiations compared to conventional dose rate (CONV) irradiations while being isotoxic to the tumor has been termed “FLASH effect” and has been observed when… read more here.
Keywords: effect; flash effect; late reacting; reacting tissues ... See more keywords
The flash effect in electronic conductors: The case of amorphous carbon fibers
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DOI: 10.1016/j.scriptamat.2020.01.003
Abstract: Abstract Fibers of amorphous carbon are deployed as a model system to explore the incidence of flash in electronic conductors. The onset of flash is confirmed by a non-linear rise in conductivity and intense electroluminescence.… read more here.
Keywords: carbon; flash effect; electronic conductors; amorphous carbon ... See more keywords
Fractionated FLASH radiation in xenografted lung tumors induced FLASH effect at a split dose of 2 Gy.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of radiation biology"
DOI: 10.1080/09553002.2023.2194403
Abstract: PURPOSE To explore the minimum split dose of FLASH radiotherapy (FLASH). MATERIAL AND METHODS Lungs of nude mice were used to verify the capacity of normal tissue sparing of FLASH, while tumor-bearing nude mice were… read more here.
Keywords: flash effect; split dose; effect; tumor ... See more keywords
Determining the parameter space for effective oxygen depletion for FLASH radiation therapy
Sign Up to like & getrecommendations! Published in 2021 at "Physics in Medicine and Biology"
DOI: 10.1088/1361-6560/abe2ea
Abstract: There has been a recent revival of interest in the FLASH effect, after experiments have shown normal tissue sparing capabilities of ultra-high-dose-rate radiation with no compromise on tumour growth restraint. A model has been developed… read more here.
Keywords: oxygen; flash; flash effect; depletion ... See more keywords
Independent Reproduction of the FLASH Effect on the Gastrointestinal Tract: A Multi-Institutional Comparative Study
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DOI: 10.3390/cancers15072121
Abstract: Simple Summary The ability of ultra-high dose rate FLASH radiation therapy (RT) to reduce normal tissue toxicity without affecting tumor response relative to conventional dose rate radiation therapy could fundamentally change the way we treat… read more here.
Keywords: effect; flash effect; flash; radiation ... See more keywords