A potential revolution in cancer treatment: A topical review of FLASH radiotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.13790
Abstract: Abstract FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR) (≥40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies show that the UHDR RT… read more here.
Keywords: treatment; flash; flash radiotherapy; flash irradiation ... See more keywords
Regeneration of a metal oxide catalyst with polyvinylpyrrolidone under xenon flash irradiation for repetitive hydrogen generation
Sign Up to like & getrecommendations! Published in 2020 at "AIP Advances"
DOI: 10.1063/5.0018309
Abstract: In thermochemical water splitting cycles using an oxide catalyst, the temperature required for the catalyst reduction process (1000 °C–2500 °C) is much higher than that required for the hydrogen generation process (800 °C–1500 °C). Accordingly,… read more here.
Keywords: hydrogen; oxide catalyst; flash irradiation; hydrogen generation ... See more keywords
FLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence
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DOI: 10.1158/1078-0432.ccr-19-1440
Abstract: Purpose: One of the main limitations to anticancer radiotherapy lies in irreversible damage to healthy tissues located within the radiation field. “FLASH” irradiation at very high dose-rate is a new treatment modality that has been… read more here.
Keywords: flash; damage; irradiation; flash irradiation ... See more keywords
FLASH Irradiation Results in Reduced Severe Skin Toxicity Compared to Conventional-Dose-Rate Irradiation
Sign Up to like & getrecommendations! Published in 2020 at "Radiation Research"
DOI: 10.1667/rade-20-00090
Abstract: Radiation therapy, along with surgery and chemotherapy, is one of the main treatments for cancer. While radiotherapy is highly effective in the treatment of localized tumors, its main limitation is its toxicity to normal tissue.… read more here.
Keywords: dose rate; conv irradiation; toxicity; irradiation results ... See more keywords
Mitochondrial Damage Response and Fate of Normal Cells Exposed to FLASH Irradiation with Protons
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DOI: 10.1667/rade-21-00181.1
Abstract: Radiation therapy (RT) plays an important role in cancer treatment. The clinical efficacy of radiation therapy is, however, limited by normal tissue toxicity in areas surrounding the irradiated tumor. Compared to conventional radiation therapy (CONV-RT)… read more here.
Keywords: normal cells; damage; flash irradiation; radiation ... See more keywords
Comet Assay Profiling of FLASH-Induced Damage: Mechanistic Insights into the Effects of FLASH Irradiation
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087195
Abstract: Numerous studies have demonstrated the normal tissue-sparing effects of ultra-high dose rate ‘FLASH’ irradiation in vivo, with an associated reduction in damage burden being reported in vitro. Towards this, two key radiochemical mechanisms have been… read more here.
Keywords: induced damage; damage; flash irradiation; damage burden ... See more keywords