A potential revolution in cancer treatment: A topical review of FLASH radiotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.13790
Abstract: Abstract FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR) (≥40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies show that the UHDR RT… read more here.
Keywords: treatment; flash; flash radiotherapy; flash irradiation ... See more keywords
FLASH Radiotherapy: Newsflash or Flash in The Pan?
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DOI: 10.1002/mp.13685
Abstract: Ionizing radiation with ultra-high dose rates (>40 Gy/s), known as FLASH, has drawn great attention since its introduction in 20141 . It has been shown to markedly reduce radiation toxicity to normal healthy tissues while… read more here.
Keywords: flash; radiotherapy newsflash; radiotherapy; flash radiotherapy ... See more keywords
Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry
Sign Up to like & getrecommendations! Published in 2022 at "Medical Physics"
DOI: 10.1002/mp.15473
Abstract: Abstract Purpose FLASH radiotherapy (RT) is an emerging technique in which beams with ultra‐high dose rates (UH‐DR) and dose per pulse (UH‐DPP) are used. Commercially available active real‐time dosimeters have been shown to be unsuitable… read more here.
Keywords: novel diamond; flash radiotherapy; detector; response ... See more keywords
Application of a novel diamond detector for commissioning of FLASH radiotherapy electron beams
Sign Up to like & getrecommendations! Published in 2022 at "Medical Physics"
DOI: 10.1002/mp.15782
Abstract: Abstract Purpose A diamond detector prototype was recently proposed by Marinelli et al. (Medical Physics 2022, https://doi.org/10.1002/mp.15473) for applications in ultrahigh‐dose‐per‐pulse (UH‐DPP) and ultrahigh‐dose‐rate (UH‐DR) beams, as used in FLASH radiotherapy (FLASH‐RT). In the present… read more here.
Keywords: diamond detector; beam; flash radiotherapy; electron ... See more keywords
Commissioning a 250 MeV research beamline for proton FLASH radiotherapy preclinical experiments.
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DOI: 10.1002/mp.16364
Abstract: BACKGROUND The potential reduction of normal tissue toxicities during FLASH radiotherapy (FLASH-RT) has inspired many efforts to investigate its underlying mechanism and to translate it into the clinic. Such investigations require experimental platforms of FLASH-RT… read more here.
Keywords: research; research beamline; flash radiotherapy; 250 mev ... See more keywords
Ultra-high dose-rate (FLASH) radiotherapy: Generation of early, transient, strongly acidic spikes in the irradiated tumor environment.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique"
DOI: 10.1016/j.canrad.2019.11.004
Abstract: Monte Carlo simulations of γ/fast electron-radiolysis of water show that the in situ formation of H3O+ temporarily renders each "native" isolated spur/track region very acidic. For pulsed (FLASH) irradiation with high dose rate, this early… read more here.
Keywords: high dose; flash radiotherapy; dose rate;
Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
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DOI: 10.1158/1078-0432.ccr-22-0262
Abstract: Abstract Purpose: The FLASH effect is characterized by normal tissue sparing without compromising tumor control. Although demonstrated in various preclinical models, safe translation of FLASH-radiotherapy stands to benefit from larger vertebrate animal models. Based on… read more here.
Keywords: nasal planum; flash radiotherapy; radiotherapy; mini pigs ... See more keywords
Establishment and Initial Experience of Clinical FLASH Radiotherapy in Canine Cancer Patients
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DOI: 10.3389/fonc.2021.658004
Abstract: FLASH radiotherapy has emerged as a treatment technique with great potential to increase the differential effect between normal tissue toxicity and tumor response compared to conventional radiotherapy. To evaluate the feasibility of FLASH radiotherapy in… read more here.
Keywords: canine cancer; cancer patients; radiotherapy; flash radiotherapy ... See more keywords
Do We Preserve Tumor Control Probability (TCP) in FLASH Radiotherapy? A Model-Based Analysis
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DOI: 10.3390/ijms24065118
Abstract: Reports of concurrent sparing of normal tissue and iso-effective treatment of tumors at ultra-high dose-rates (uHDR) have fueled the growing field of FLASH radiotherapy. However, iso-effectiveness in tumors is often deduced from the absence of… read more here.
Keywords: tumor control; flash radiotherapy; radiotherapy; based analysis ... See more keywords
FLASH radiotherapy: an emerging approach in radiation therapy
Sign Up to like & getrecommendations! Published in 2022 at "Reports of Practical Oncology and Radiotherapy"
DOI: 10.5603/rpor.a2022.0038
Abstract: FLASH radiotherapy (RT) is a technique involving the delivery of ultra-high dose rate radiation to the target. FLASH-RT has been shown to reduce radiation-induced toxicity in healthy tissues without compromising the anti-cancer effects of treatment… read more here.
Keywords: radiation therapy; flash radiotherapy; radiotherapy; radiation ... See more keywords