Articles with "flat dosing" as a keyword



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Population pharmacokinetic analysis of danvatirsen supporting flat dosing switch

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Published in 2019 at "Journal of Pharmacokinetics and Pharmacodynamics"

DOI: 10.1007/s10928-019-09619-6

Abstract: Danvatirsen is a Generation 2.5 antisense oligonucleotide under clinical development. Population PK modelling was conducted using data from 3 available danvatirsen Phase I/II studies in oncology patients to investigate the impact of flat dosing on… read more here.

Keywords: flat dosing; analysis; population pharmacokinetic; model ... See more keywords