Predicting the Substrate Scope of the Flavin‐Dependent Halogenase BrvH
Sign Up to like & getrecommendations! Published in 2020 at "Chembiochem"
DOI: 10.1002/cbic.202000444
Abstract: The recently described flavin‐dependent halogenase BrvH is able to catalyse both the bromination and chlorination of indole, but shows significantly higher bromination activity. BrvH was annotated as a tryptophan halogenase, but does not accept tryptophan… read more here.
Keywords: flavin dependent; halogenase; dependent halogenase; model ... See more keywords
Engineered Bacterial Flavin‐Dependent Monooxygenases for the Regiospecific Hydroxylation of Polycyclic Phenols
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202100480
Abstract: 4‐Hydroxyphenylacetate 3‐hydroxylase (4HPA3H), a flavin‐dependent monooxygenase from E. coli that catalyzes the hydroxylation of monophenols to catechols, was modified by rational redesign to convert also more bulky substrates, especially phenolic natural products like phenylpropanoids, flavones… read more here.
Keywords: flavin dependent; monooxygenases regiospecific; bacterial flavin; dependent monooxygenases ... See more keywords
Flavin‐Dependent Halogenases: Emerging Enzymes and New Functions
Sign Up to like & getrecommendations! Published in 2025 at "ChemCatChem"
DOI: 10.1002/cctc.202500558
Abstract: Flavin‐dependent halogenases (FDHs) are remarkable biocatalysts because they can catalyze the precise installation of carbon‐halogen (C─X) bonds in organic compounds due to their specific catalytic features. Recently, many notable FDHs with potential applications in diverse… read more here.
Keywords: new functions; flavin dependent; emerging enzymes; enzymes new ... See more keywords
Asymmetric catalysis by flavin-dependent halogenases.
Sign Up to like & getrecommendations! Published in 2023 at "Chirality"
DOI: 10.1002/chir.23550
Abstract: In nature, flavin-dependent halogenases (FDHs) catalyze site-selective chlorination and bromination of aromatic natural products. This ability has led to extensive efforts to engineer FDHs for selective chlorination, bromination, and iodination of electron rich aromatic compounds.… read more here.
Keywords: flavin dependent; catalysis; asymmetric catalysis; dependent halogenases ... See more keywords
Comparative Activity-Based Flavin-Dependent Oxidase Profiling.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6439-0_7
Abstract: Activity-based protein profiling (ABPP) has become a powerful chemoproteomic technology allowing for the dissection of complex ligand-protein interactions in their native cellular environment. One of the biggest challenges for ABPP is the extension of the… read more here.
Keywords: flavin dependent; comparative activity; activity based; dependent oxidase ... See more keywords
Flavin-dependent epitranscriptomic world.
Sign Up to like & getrecommendations! Published in 2017 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2017.06.011
Abstract: RNAs molecules fulfill key roles in the expression and regulation of the genetic information stored within the DNA chromosomes. In addition to the four canonical bases, U, C, A and G, RNAs harbor various chemically… read more here.
Keywords: chemistry; dependent epitranscriptomic; flavin dependent; epitranscriptomic world ... See more keywords
From Ground-State to Excited-State Activation Modes: Flavin-Dependent "Ene"-Reductases Catalyzed Non-natural Radical Reactions.
Sign Up to like & getrecommendations! Published in 2024 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.4c00129
Abstract: ConspectusEnzymes are desired catalysts for chemical synthesis, because they can be engineered to provide unparalleled levels of efficiency and selectivity. Yet, despite the astonishing array of reactions catalyzed by natural enzymes, many reactivity patterns found… read more here.
Keywords: flavin dependent; radical reactions; dependent ene; ene reductases ... See more keywords
Kinetic and Structural Characterization of a Flavin-Dependent Putrescine N-Hydroxylase from Acinetobacter baumannii.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00493
Abstract: Acinetobacter baumannii is a Gram-negative opportunistic pathogen that causes nosocomial infections, especially among immunocompromised individuals. The rise of multidrug resistant strains of A. baumannii has limited the use of standard antibiotics, highlighting a need for… read more here.
Keywords: flavin dependent; fbsi; acinetobacter baumannii;
Mechanism of Nitrone Formation by a Flavin-Dependent Monooxygenase
Sign Up to like & getrecommendations! Published in 2024 at "Biochemistry"
DOI: 10.1021/acs.biochem.3c00656
Abstract: OxaD is a flavin-dependent monooxygenase (FMO) responsible for catalyzing the oxidation of an indole nitrogen atom, resulting in the formation of a nitrone. Nitrones serve as versatile intermediates in complex syntheses, including challenging reactions like… read more here.
Keywords: flavin; flavin dependent; dependent monooxygenase; mechanism ... See more keywords
The Oxidase Reaction of Flavin-Dependent Thymidylate Synthase Reveals the Nature of Inhibitor Binding.
Sign Up to like & getrecommendations! Published in 2025 at "Biochemistry"
DOI: 10.1021/acs.biochem.5c00510
Abstract: Escalating antimicrobial resistance presents an urgent need for novel antibiotics, particularly against Mycobacterium tuberculosis (M. tb), which claims 1.5 million lives annually. A promising avenue for antibiotic development is inhibiting DNA biosynthesis by targeting Thymidylate… read more here.
Keywords: reaction; flavin dependent; oxidase reaction; inhibitor ... See more keywords
The Promiscuous Flavin-Dependent Monooxygenase PboD from Aspergillus ustus Increases the Structural Diversity of Hydroxylated Pyrroloindoline Diketopiperazines.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.4c00127
Abstract: The potential of natural products as pharmaceutical and agricultural agents is based on their large structural diversity, resulting in part from modifications of the backbone structure by tailoring enzymes during biosynthesis. Flavin-dependent monooxygenases (FMOs), as… read more here.
Keywords: flavin dependent; structural diversity; natural products; pbod ... See more keywords