Flaviviridae viruses use a common molecular mechanism to escape nucleoside analogue inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.068
Abstract: The RNA-dependent RNA polymerases of Flaviviridae viruses are crucial for replication. The Flaviviridae polymerase is organized into structural motifs (A-G), with motifs F, A, C and E containing interrogating, priming and catalytic substrate-interacting sites. Modified… read more here.
Keywords: flaviviridae viruses; analogue inhibitors; threonine; nucleoside analogue ... See more keywords
Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species.
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DOI: 10.1039/c9md00200f
Abstract: Infections with Flaviviridae viruses, such as hepatitis C virus (HCV) and dengue virus (DENV) pose global health threats. Infected individuals are at risk of developing chronic liver failure or haemorrhagic fever respectively, often with a… read more here.
Keywords: strategy towards; trypanosoma species; towards potent; hybridization strategy ... See more keywords
In Vivo Dynamics of Reporter Flaviviridae Viruses
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DOI: 10.1128/jvi.01191-19
Abstract: In vivo applications of reporter viruses are necessary to understand viral pathogenesis and provide a robust platform for antiviral development. In developing such applications, determination of an ideal locus to accommodate foreign genes is important,… read more here.
Keywords: propagation; recombinant viruses; virus; foreign genes ... See more keywords
Characterization of Recombinant Flaviviridae Viruses Possessing a Small Reporter Tag
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01582-17
Abstract: ABSTRACT The family Flaviviridae consists of four genera, Flavivirus, Pestivirus, Pegivirus, and Hepacivirus, and comprises important pathogens of human and animals. Although the construction of recombinant viruses carrying reporter genes encoding fluorescent and bioluminescent proteins… read more here.
Keywords: viruses possessing; recombinant flaviviridae; flaviviridae viruses; luciferase ... See more keywords