Erythrosin B is a potent and broad‐spectrum orthosteric inhibitor of the flavivirus NS2B‐NS3 protease
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.12.018
Abstract: Abstract Many flaviviruses, such as Zika virus (ZIKV), Dengue virus (DENV1‐4) and yellow fever virus (YFV), are significant human pathogens. Infection with ZIKV, an emerging mosquito‐borne flavivirus, is associated with increased risk of microcephaly in… read more here.
Keywords: inhibitor; erythrosin; zikv; flavivirus ... See more keywords
Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.03.004
Abstract: We report the design, synthesis, and biological evaluation of a class of 1H-pyrido[2,1-b][1,3]benzothiazol-1-ones originated from compound 1, previously identified as anti-flavivirus agent. Some of the new compounds showed activity in low μM range with reasonable… read more here.
Keywords: spectrum anti; anti flavivirus; flavivirus pyridobenzothiazolones; flavivirus ... See more keywords
The rearrangement of motif F in the flavivirus RNA-directed RNA polymerase.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.11.009
Abstract: In the flavivirus genus, the non-structural protein NS5 plays a central role in RNA viral replication and constitutes a major target for drug discovery. One of the prime challenges in the study of NS5 protein… read more here.
Keywords: ns5 protein; flavivirus; rna polymerase;
Added value of IgA antibodies against Zika virus non-structural protein 1 in the diagnosis of acute Zika virus infections.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of virological methods"
DOI: 10.1016/j.jviromet.2019.02.005
Abstract: Zika virus (ZIKV) is a mosquito-borne flavivirus posing a public health threat due to its association with neurological complications in newborns and adults. In flavivirus-endemic areas, coming mosquito seasons will require the differentiation of primary… read more here.
Keywords: iga; zikv; flavivirus; zika virus ... See more keywords
The flavivirus capsid protein: Structure, function and perspectives towards drug design.
Sign Up to like & getrecommendations! Published in 2017 at "Virus research"
DOI: 10.1016/j.virusres.2016.10.005
Abstract: Flaviviruses, such as dengue and zika viruses, are etiologic agents transmitted to humans mainly by arthropods and are of great epidemiological interest. The flavivirus capsid protein is a structural element required for the viral nucleocapsid… read more here.
Keywords: drug; flavivirus; capsid protein; flavivirus capsid ... See more keywords
Small Molecules Targeting the Flavivirus E Protein with Broad-Spectrum Activity and Antiviral Efficacy in Vivo.
Sign Up to like & getrecommendations! Published in 2019 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.8b00322
Abstract: Vaccines and antivirals to combat dengue, Zika, and other flavivirus pathogens present a major, unmet medical need. Vaccine development has been severely challenged by the antigenic diversity of these viruses and the propensity of non-neutralizing,… read more here.
Keywords: protein; activity; flavivirus; spectrum activity ... See more keywords
Species composition, seasonal prevalence and flavivirus occurrence of mosquitoes in Daegu and Gunwi, South Korea during the period of 2015–2016
Sign Up to like & getrecommendations! Published in 2018 at "Entomological Research"
DOI: 10.1111/1748-5967.12327
Abstract: As the vector‐borne diseases rapidly increased due to climate change, we investigated the incidence of flavivirus occurrence among female mosquito species in urban and rural study sites in Daegu and Gunwi, South Korea using Realtime… read more here.
Keywords: gunwi south; south korea; daegu gunwi; flavivirus ... See more keywords
A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus
Sign Up to like & getrecommendations! Published in 2019 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aax7888
Abstract: Insect-specific Binjari virus facilitates the production of chimeric virus particles of flavivirus pathogens for diagnostics and vaccines. Fighting flavi with flavi Insect-transmitted flaviviruses can cause hemorrhagic fever in humans and contribute to morbidity and mortality… read more here.
Keywords: insect; insect specific; new insect; flavivirus ... See more keywords
First Isolation of a Novel Aquatic Flavivirus from Chinook Salmon (Oncorhynchus tshawytscha) and Its In Vivo Replication in a Piscine Animal Model
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DOI: 10.1128/jvi.00337-20
Abstract: Chinook salmon are a keystone fish species of great ecological and commercial significance in their native northern Pacific range and in regions to which they have been introduced. Threats to salmon populations include habitat degradation,… read more here.
Keywords: first isolation; flavivirus; salmon; chinook salmon ... See more keywords
Mechanism through Which Retrocyclin Targets Flavivirus Multiplication
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DOI: 10.1128/jvi.00560-21
Abstract: Retrocyclin is an artificially humanized circular θ-defensin peptide, containing 18 residues, previously reported to possess broad antimicrobial activity. In this study, we found that retrocyclin-101 inhibited flavivirus (ZIKV and JEV) infections. Retrocyclin-101 inhibited NS2B-NS3 serine… read more here.
Keywords: flavivirus; activity; 101 inhibited; protease ... See more keywords
Binding of Duck Tembusu Virus Nonstructural Protein 2A to Duck STING Disrupts Induction of Its Signal Transduction Cascade To Inhibit Beta Interferon Induction
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.01850-19
Abstract: Flavivirus infections are transmitted through mosquitos or ticks and lead to significant morbidity and mortality worldwide with a spectrum of manifestations. Infection with an emerging flavivirus, DTMUV, manifests with clinical symptoms that include lesions of… read more here.
Keywords: ns2a; flavivirus; transduction cascade; signal transduction ... See more keywords