Erythrosin B is a potent and broad‐spectrum orthosteric inhibitor of the flavivirus NS2B‐NS3 protease
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.12.018
Abstract: Abstract Many flaviviruses, such as Zika virus (ZIKV), Dengue virus (DENV1‐4) and yellow fever virus (YFV), are significant human pathogens. Infection with ZIKV, an emerging mosquito‐borne flavivirus, is associated with increased risk of microcephaly in… read more here.
Keywords: inhibitor; erythrosin; zikv; flavivirus ... See more keywords
Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.03.004
Abstract: We report the design, synthesis, and biological evaluation of a class of 1H-pyrido[2,1-b][1,3]benzothiazol-1-ones originated from compound 1, previously identified as anti-flavivirus agent. Some of the new compounds showed activity in low μM range with reasonable… read more here.
Keywords: spectrum anti; anti flavivirus; flavivirus pyridobenzothiazolones; flavivirus ... See more keywords
The rearrangement of motif F in the flavivirus RNA-directed RNA polymerase.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.11.009
Abstract: In the flavivirus genus, the non-structural protein NS5 plays a central role in RNA viral replication and constitutes a major target for drug discovery. One of the prime challenges in the study of NS5 protein… read more here.
Keywords: ns5 protein; flavivirus; rna polymerase;
Added value of IgA antibodies against Zika virus non-structural protein 1 in the diagnosis of acute Zika virus infections.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of virological methods"
DOI: 10.1016/j.jviromet.2019.02.005
Abstract: Zika virus (ZIKV) is a mosquito-borne flavivirus posing a public health threat due to its association with neurological complications in newborns and adults. In flavivirus-endemic areas, coming mosquito seasons will require the differentiation of primary… read more here.
Keywords: iga; zikv; flavivirus; zika virus ... See more keywords
The flavivirus capsid protein: Structure, function and perspectives towards drug design.
Sign Up to like & getrecommendations! Published in 2017 at "Virus research"
DOI: 10.1016/j.virusres.2016.10.005
Abstract: Flaviviruses, such as dengue and zika viruses, are etiologic agents transmitted to humans mainly by arthropods and are of great epidemiological interest. The flavivirus capsid protein is a structural element required for the viral nucleocapsid… read more here.
Keywords: drug; flavivirus; capsid protein; flavivirus capsid ... See more keywords
Small Molecules Targeting the Flavivirus E Protein with Broad-Spectrum Activity and Antiviral Efficacy in Vivo.
Sign Up to like & getrecommendations! Published in 2019 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.8b00322
Abstract: Vaccines and antivirals to combat dengue, Zika, and other flavivirus pathogens present a major, unmet medical need. Vaccine development has been severely challenged by the antigenic diversity of these viruses and the propensity of non-neutralizing,… read more here.
Keywords: protein; activity; flavivirus; spectrum activity ... See more keywords
A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition
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DOI: 10.1038/s42003-024-05768-8
Abstract: Flaviviruses, including Zika virus (ZIKV) and Dengue virus (DENV), rely on their non-structural protein 5 (NS5) for both replication of viral genome and suppression of host IFN signaling. DENV and ZIKV NS5s were shown to… read more here.
Keywords: species specific; flavivirus; selection mechanism; flavivirus ns5 ... See more keywords
Species composition, seasonal prevalence and flavivirus occurrence of mosquitoes in Daegu and Gunwi, South Korea during the period of 2015–2016
Sign Up to like & getrecommendations! Published in 2018 at "Entomological Research"
DOI: 10.1111/1748-5967.12327
Abstract: As the vector‐borne diseases rapidly increased due to climate change, we investigated the incidence of flavivirus occurrence among female mosquito species in urban and rural study sites in Daegu and Gunwi, South Korea using Realtime… read more here.
Keywords: gunwi south; south korea; daegu gunwi; flavivirus ... See more keywords
Host‐feeding preferences of Culex pipiens and its potential significance for flavivirus transmission in the Camargue, France
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DOI: 10.1111/mve.12802
Abstract: The spread of the West Nile (WNV) and Usutu (USUV) flaviviruses in Europe in recent decades highlights the urgent need to understand the transmission networks of these pathogens as a basis for effective decision‐making. These… read more here.
Keywords: transmission; flavivirus; host; culex pipiens ... See more keywords
A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus
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DOI: 10.1126/scitranslmed.aax7888
Abstract: Insect-specific Binjari virus facilitates the production of chimeric virus particles of flavivirus pathogens for diagnostics and vaccines. Fighting flavi with flavi Insect-transmitted flaviviruses can cause hemorrhagic fever in humans and contribute to morbidity and mortality… read more here.
Keywords: insect; insect specific; new insect; flavivirus ... See more keywords
First Isolation of a Novel Aquatic Flavivirus from Chinook Salmon (Oncorhynchus tshawytscha) and Its In Vivo Replication in a Piscine Animal Model
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DOI: 10.1128/jvi.00337-20
Abstract: Chinook salmon are a keystone fish species of great ecological and commercial significance in their native northern Pacific range and in regions to which they have been introduced. Threats to salmon populations include habitat degradation,… read more here.
Keywords: first isolation; flavivirus; salmon; chinook salmon ... See more keywords