Molecular Determinants of Tissue Specificity of Flavivirus Nonstructural Protein 1 Interaction with Endothelial Cells
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DOI: 10.1128/jvi.00661-22
Abstract: Flavivirus NS1 is secreted into the bloodstream from infected cells during a viral infection. Dengue virus NS1 contributes to severe dengue pathology such as endothelial dysfunction and vascular leak independently of the virus. ABSTRACT Members… read more here.
Keywords: endothelial cells; pathology; flavivirus ns1; vascular leak ... See more keywords
Flavivirus NS1 Triggers Tissue-Specific Disassembly of Intercellular Junctions Leading to Barrier Dysfunction and Vascular Leak in a GSK-3β-Dependent Manner
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DOI: 10.3390/pathogens11060615
Abstract: The flavivirus nonstructural protein 1 (NS1) is secreted from infected cells and contributes to endothelial barrier dysfunction and vascular leak in a tissue-dependent manner. This phenomenon occurs in part via disruption of the endothelial glycocalyx… read more here.
Keywords: barrier dysfunction; dependent manner; flavivirus ns1; gsk ... See more keywords