Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraints
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49758-0
Abstract: Zika and dengue virus nonstructural protein 5 antagonism of STAT2, a critical interferon signaling transcription factor, to suppress the host interferon response is required for viremia and pathogenesis in a vertebrate host. This affects viral… read more here.
Keywords: evolution; stat2 resistance; resistance; resistance flavivirus ... See more keywords
A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-05768-8
Abstract: Flaviviruses, including Zika virus (ZIKV) and Dengue virus (DENV), rely on their non-structural protein 5 (NS5) for both replication of viral genome and suppression of host IFN signaling. DENV and ZIKV NS5s were shown to… read more here.
Keywords: species specific; flavivirus; selection mechanism; flavivirus ns5 ... See more keywords
Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00418-22
Abstract: The methyltransferase (MTase) domain of flavivirus NS5 is unique in harboring guanylyltransferase (GTase), N7 MTase, and 2′-O MTase activities, playing a central role in viral RNA capping. However, the detailed mechanisms of the multistep capping… read more here.
Keywords: mtase; guanylyltransferase; gmp arginine; crystal structures ... See more keywords