Synthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase.
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DOI: 10.1016/j.bioorg.2019.102960
Abstract: In a search for novel multifunctional anti-Alzheimer agents, a congeneric set of seventeen flavone-8-acrylamide derivatives (8a─q) were synthesized and evaluated for their cholinesterase inhibitory, antioxidant, neuroprotective and modulation of Aβ aggregation activities. The target compounds… read more here.
Keywords: acrylamide derivatives; alzheimer agents; flavone acrylamide; anti alzheimer ... See more keywords