Flavones and flavonols may have clinical potential as CK2 inhibitors in cancer therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2020.109723
Abstract: The serine-threonine kinase CK2, which targets over 300 cellular proteins, is overexpressed in all cancers, presumably reflecting its ability to promote proliferation, spread, and survival through a wide range of complementary mechanisms. Via an activating… read more here.
Keywords: flavones flavonols; cancer; ck2 inhibitors; inhibitors cancer ... See more keywords
Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-20974-2
Abstract: Gut microbial transformations of flavonoids, an enormous class of polyphenolic compounds abundant in plant-based diets, are closely associated with human health. However, the enzymes that initiate the gut microbial metabolism of flavones and flavonols, the… read more here.
Keywords: gut; reductase; gut microbial; flavones flavonols ... See more keywords
Flavones, Flavonols, Lignans, and Caffeic Acid Derivatives from Dracocephalum moldavica and Their In Vitro Effects on Multiple Myeloma and Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214219
Abstract: Phenolic plant constituents are well known for their health-promoting and cancer chemopreventive properties, and products containing such constituents are therefore readily consumed. In the present work, we isolated 13 phenolic constituents of four different compound… read more here.
Keywords: flavonols lignans; lignans caffeic; myeloma; acid derivatives ... See more keywords
In Vivo Antistress Effects of Synthetic Flavonoids in Mice: Behavioral and Biochemical Approach
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27041402
Abstract: Natural flavonoids, in addition to some of their synthetic derivatives, are recognized for their remarkable medicinal properties. The present study was designed to investigate the in vitro antioxidant and in vivo antistress effect of synthetic… read more here.
Keywords: vivo antistress; flavonoids mice; effects synthetic; antistress effects ... See more keywords