New flavonoid-based compound synthesis strategy for antihypertensive drug development.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117512
Abstract: Hypertension is one of the leading causes of mortality in relation to the cardiovascular conditions and easily the most overlooked and poorly managed disease in mankind. With well over 200 drugs available in the market… read more here.
Keywords: flavonoid based; compound synthesis; synthesis strategy; new flavonoid ... See more keywords
Understanding the Role of Flavonoid Based Small Molecules in Modulating the Oncogenic Protein-Protein Interactions: A Quest for Therapeutic Arsenal
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131511
Abstract: Abstract We explored the anticancer activity of two synthetic flavonoid-based small molecules, HMDC and HMDF, with bioactive methylenedioxy functionality. HMDF inhibited the proliferation of the p53 wild-type (NCIH460 and A549), and p53 null (NCIH1299) non-small… read more here.
Keywords: protein; flavonoid based; understanding role; small molecules ... See more keywords
Synthesis and biological evaluation of flavonoid-based IP6K2 inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2193866
Abstract: Abstract Inositol polyphosphates (IPs) are a group of inositol metabolites that act as secondary messengers for external signalling cues. They play various physiological roles such as insulin release, telomere length maintenance, cell metabolism, and aging.… read more here.
Keywords: synthesis biological; biological evaluation; ip6k2 inhibitors; compound 20s ... See more keywords