Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.06.28.498039
Abstract: mTORC1 regulates cell growth and catabolism in response to fluctuations in nutrients through phosphorylation of key substrates. The tumor suppressor FLCN is a RagC GTPase activating protein (GAP) that regulates mTORC1 phosphorylation of TFEB, controlling… read more here.
Keywords: flcn; flcn ragc; selective mtorc1; mtorc1 ... See more keywords
FLCN Regulates HIF2α Nuclear Import and Proliferation of Clear Cell Renal Cell Carcinoma
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DOI: 10.3389/fmolb.2020.00121
Abstract: Aims and Hypothesis: This study aims to explore the specific molecular mechanism of folliculin (FLCN)-induced proliferation, migration, and invasion in clear cell renal cell carcinoma (ccRCC) and to investigate the relationship of FLCN and HIF2α.… read more here.
Keywords: cell renal; flcn; proliferation; hif2 ... See more keywords
Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.61630
Abstract: Germline mutations in the Folliculin (FLCN) tumor suppressor gene cause Birt–Hogg–Dubé (BHD) syndrome, a rare autosomal dominant disorder predisposing carriers to kidney tumors. FLCN is a conserved, essential gene linked to diverse cellular processes but… read more here.
Keywords: tubular epithelial; human renal; flcn; interferon response ... See more keywords