Insertion of Small Flexible Linkers as a Useful Scaffold Hopping Tool in Agrochemistry.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c07971
Abstract: Inserting small flexible linkers of only one- to three-atom chain lengths into a molecular backbone is an important scaffold hopping manipulation. Analogues derived from biologically active compounds through the utilization of such a strategy are… read more here.
Keywords: useful scaffold; scaffold hopping; small flexible; insertion small ... See more keywords
Discovery of Diphenoxy Derivatives with Flexible Linkers as Ligands for β-amyloid Plaques.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c00537
Abstract: The highly rigid and planar scaffolds with π-conjugated systems have been widely considered to be indispensable for Aβ binding ligands. In this study, a library of diphenoxy compounds with different types of more flexible linkers… read more here.
Keywords: flexible linkers; derivatives flexible; discovery diphenoxy; ligands amyloid ... See more keywords