Septins promote caspase activity and coordinate mitochondrial apoptosis.
Sign Up to like & getrecommendations! Published in 2022 at "Cytoskeleton"
DOI: 10.1002/cm.21696
Abstract: Apoptosis is a form of regulated cell death essential for embryonic development and tissue homeostasis. Apoptosis also plays key roles during bacterial infection, yet some intracellular bacterial pathogens (such as Shigella flexneri, whose lipopolysaccharide can… read more here.
Keywords: mitochondrial apoptosis; caspase; infection; flexneri ... See more keywords
Antimicrobial and anti-biofilm activity of thymoquinone against Shigella flexneri.
Sign Up to like & getrecommendations! Published in 2021 at "Applied microbiology and biotechnology"
DOI: 10.1007/s00253-021-11295-x
Abstract: Shigella flexneri (Sh. flexneri), a common foodborne pathogen, has become one of the main threats to food safety and human health due to its high pathogenicity and persistent infection. The objective of this study was… read more here.
Keywords: antimicrobial anti; anti biofilm; flexneri; biofilm ... See more keywords
Evolutionary histories and antimicrobial resistance in Shigella flexneri and Shigella sonnei in Southeast Asia
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-01905-9
Abstract: Conventional disease surveillance for shigellosis in developing country settings relies on serotyping and low-resolution molecular typing, which fails to contextualise the evolutionary history of the genus. Here, we interrogated a collection of 1,804 Shigella whole… read more here.
Keywords: sonnei; shigella; southeast asia; flexneri ... See more keywords
Gastrointestinal signals in supplemented media reveal a role in adherence for the Shigella flexneri sap autotransporter gene
Sign Up to like & getrecommendations! Published in 2024 at "Gut Microbes"
DOI: 10.1080/19490976.2024.2331985
Abstract: ABSTRACT Shigella flexneri causes severe diarrheal disease worldwide. While many aspects of pathogenesis have been elucidated, significant knowledge gaps remain regarding the role of putative chromosomally-encoded virulence genes. The uncharacterized sap gene encoded on the… read more here.
Keywords: role; flexneri; adherence; gene ... See more keywords
Dissemination of Multidrug-Resistant Shigella flexneri and Shigella sonnei with Class 1, Class 2, and Atypical Class 1 Integrons in China.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial drug resistance"
DOI: 10.1089/mdr.2018.0229
Abstract: Background: Emergence of multidrug-resistant Shigella, a major causative agent of bacterial dysentery, has generated many concerns not only in China but also worldwide. However, the prevalence of Shigella resistance caused by integron in the nonpopular… read more here.
Keywords: class; sonnei; shigella; atypical class ... See more keywords
Virulence plasmid pINV as a genetic signature for Shigella flexneri phylogeny
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Genomics"
DOI: 10.1099/mgen.0.000846
Abstract: Shigella flexneri is a major health burden in low- and middle-income countries, where it is a leading cause of mortality associated with diarrhoea in children, and shows an increasing incidence among travellers and men having… read more here.
Keywords: shigella flexneri; pinv; plasmid; virulence ... See more keywords
WIPF2 promotes Shigella flexneri actin‐based motility and cell‐to‐cell spread
Sign Up to like & getrecommendations! Published in 2019 at "Cellular Microbiology"
DOI: 10.1111/cmi.13098
Abstract: Shigella flexneri is an intracellular pathogen that disseminates in colonic epithelial cells through actin‐based motility and formation of membrane protrusions at cell–cell contacts, that project into adjacent cells and resolve into vacuoles, from which the… read more here.
Keywords: based motility; cell cell; actin based; flexneri ... See more keywords
Selection for Phage Resistance Reduces Virulence of Shigella flexneri
Sign Up to like & getrecommendations! Published in 2021 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.01514-21
Abstract: Shigella flexneri is a facultative intracellular pathogen of humans and a leading cause of bacillary dysentery. With few effective treatments and rising antibiotic resistance in these bacteria, there is increasing interest in alternatives to classical… read more here.
Keywords: shigella flexneri; flexneri; phage; virulence ... See more keywords
Characterization of Shigella flexneri Serotype 6 Strains Isolated from Bangladesh and Identification of a New Phylogenetic Cluster
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Bacteriology"
DOI: 10.1128/jb.00406-22
Abstract: Shigella flexneri serotype 6 is one of the predominant serotypes among shigellosis cases in Bangladesh. Characterization of a novel subserotype of S. flexneri 6 (VI:E1037), agglutinated with type 6-specific antibody and anti-E1037, indicates a unique… read more here.
Keywords: shigella flexneri; serotype; flexneri serotype; e1037 ... See more keywords
A translocation-competent pore is required for Shigella flexneri to escape from the double membrane vacuole during intercellular spread
Sign Up to like & getrecommendations! Published in 2025 at "mBio"
DOI: 10.1128/mbio.01674-25
Abstract: ABSTRACT Type 3 secretion systems (T3SSs) enable bacterial virulence by translocating virulence proteins (effectors) into host cells. Shigella flexneri requires T3SS to invade and to spread between cells in the colon. To spread, S. flexneri… read more here.
Keywords: flexneri; virulence; spread cells; spread ... See more keywords
Bacteroides thetaiotaomicron Outer Membrane Vesicles Modulate Virulence of Shigella flexneri
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.02360-22
Abstract: Shigella flexneri is the causative agent of bacillary dysentery in humans. Shigella spp. are one of the leading causes of diarrheal morbidity and mortality, especially among children in low- and middle-income countries. The rise of… read more here.
Keywords: shigella flexneri; outer membrane; thetaiotaomicron; virulence ... See more keywords