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   Articles with "fli1" as a keyword



Structure and cooperative formation of a FLI1 filament on contiguous GGAA DNA sites

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaf205

Abstract: Abstract Ewing sarcoma, a pediatric cancer of bone and soft tissue, is driven in most cases by an abnormal oncogenic fusion of the N-terminal region of EWS with the C-terminal region of FLI1 (EWS–FLI1). The… read more here.

Keywords: cooperative formation; ggaa; structure; fli1 ... See more keywords

Abstract 4035: Elucidating the DNA binding dynamics of EWSR1::FLI1 using biochemical methods

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-4035

Abstract: This work signifies a breakthrough in our ability to study Ewing sarcoma by developing a protocol to purify functional WT EWSR1::FLI1. This development changes the level of detail to which we can study EWSR1::FLI1 and… read more here.

Keywords: fli1; ewsr1 fli1; binding dynamics; dna binding ... See more keywords

Synergistic Role of Endothelial ERG and FLI1 in Mediating Pulmonary Vascular Homeostasis

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recommendations! Published in 2017 at "American Journal of Respiratory Cell and Molecular Biology"

DOI: 10.1165/rcmb.2016-0200oc

Abstract: &NA; Endothelial cell (EC) activation underlies many vascular diseases, including pulmonary arterial hypertension (PAH). Several members of the E‐twenty six (ETS) family of transcription factors are important regulators of the gene network governing endothelial homeostasis,… read more here.

Keywords: homeostasis; cell; fli1; expression ... See more keywords

Cohesin Haploinsufficiency Drives Leukemic Initiation through Fli1 Upregulation in Inv(16) AML

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-200326

Abstract: Acute myeloid leukemia (AML) is a genetically diverse cancer of the bone marrow that affects approximately 20,000 new patients annually in the US alone. Many mutations drive leukemogenesis, including those in the core binding factor… read more here.

Keywords: inv smc3; initiation; inv; fli1 ... See more keywords

Integrated analysis reveals FLI1 regulates the tumor immune microenvironment via its cell-type-specific expression and transcriptional regulation of distinct target genes of immune cells in breast cancer

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recommendations! Published in 2024 at "BMC Genomics"

DOI: 10.1186/s12864-024-10174-9

Abstract: Background Immunotherapy is a practical therapeutic approach in breast cancer (BRCA), and the role of FLI1 in immune regulation has gradually been unveiled. However, the specific role of FLI1 in BRCA was conflicted; thus, additional… read more here.

Keywords: breast cancer; brca; fli1; cell ... See more keywords

A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1

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recommendations! Published in 2018 at "Genome Biology"

DOI: 10.1186/s13059-018-1594-y

Abstract: BackgroundFriend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as an oncogenic driver in hematological malignancies and promotes tumor growth in solid tumors. However, little is known about the mechanisms underlying… read more here.

Keywords: fli1; circular rna; breast; breast cancer ... See more keywords

Silencing circular RNA-friend leukemia virus integration 1 restrained malignancy of CC cells and oxaliplatin resistance by disturbing dyskeratosis congenita 1

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recommendations! Published in 2022 at "Open Life Sciences"

DOI: 10.1515/biol-2022-0036

Abstract: Abstract Circular-RNA friend leukemia virus integration 1 (circ-FLI1; hsa_circ_0000370) is a noninvasive biomarker for the diagnosis of colon carcinoma (CC). Herein, we intended to investigate its functions and competing endogenous RNA (ceRNA) mechanisms in CC… read more here.

Keywords: fli1; cell; rna; mir 197 ... See more keywords

FLI1 Induces Plaque Psoriasis and Its Inhibition Attenuates Disease Progression

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recommendations! Published in 2025 at "Journal of Inflammation Research"

DOI: 10.2147/jir.s500822

Abstract: Plaque Psoriasis Plaque psoriasis is an inflammatory skin disorder affecting nearly 2% of the world population. Despite recent advances in psoriasis treatment, there is still a need for more effective therapies. The ETS transcription factor… read more here.

Keywords: skin cells; fli1 induces; fli1; inflammatory genes ... See more keywords

Integrated Multi-Level Investigation of Friend Leukemia Integration 1 Transcription Factor as a Novel Immune-Inflammatory Biomarker in Rheumatoid Arthritis: Bridging Bioinformatics, Clinical Cohorts, and Mechanistic Validation

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recommendations! Published in 2025 at "Journal of Inflammation Research"

DOI: 10.2147/jir.s507941

Abstract: Introduction Friend Leukemia Integration 1 Transcription Factor (FLI1) has attracted attention due to its involvement in rheumatoid arthritis (RA). Nevertheless, the precise mechanism through which FLI1 contributes to RA remains elusive. We investigated the potential… read more here.

Keywords: integration transcription; transcription factor; leukemia integration; friend leukemia ... See more keywords

FLI1 and GATA1 govern TLN1 transcription: new insights into FLI1-related platelet disorders

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recommendations! Published in 2025 at "Haematologica"

DOI: 10.3324/haematol.2024.286372

Abstract: Germline variants of FLI1, essential for megakaryopoiesis, are linked to bleeding disorders, platelet aggregation defects and mild thrombocytopenia. However, the mechanisms behind these abnormalities remain unclear. This study aims to elucidate the impact of FLI1… read more here.

Keywords: platelet; fli1; patients platelets; fli1 variants ... See more keywords