Abstract 1632: Suppression of EWS-FLI1 transcription using a combination therapy of mithramycin and cyclin-dependent kinase 9 inhibition
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DOI: 10.1158/1538-7445.am2018-1632
Abstract: Background: Ewing sarcoma (ES) is a pediatric soft tissue tumor with a poor prognosis. ES is dependent on the presence and activity of the oncogenic transcription factor, EWS-FLI1, that dysregulates gene expression at hundreds of… read more here.
Keywords: ews fli1; combination therapy; transcription; fli1 driven ... See more keywords