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   Articles with "flippase" as a keyword



Developing a flippase-mediated maker recycling protocol for the oleaginous yeast Rhodosporidium toruloides

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recommendations! Published in 2018 at "Biotechnology Letters"

DOI: 10.1007/s10529-018-2542-3

Abstract: ObjectivesTo establish a recombinase flippase (FLP) and flippase recognition target (FRT) system-mediated protocol for post-integration excision of exogenous DNA fragments in the oleaginous yeast Rhodosporidium toruloides.ResultsBinary vectors were constructed to harbor FLP expressing cassette together… read more here.

Keywords: developing flippase; flippase; oleaginous yeast; yeast rhodosporidium ... See more keywords
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Visualizing conformation transitions of the Lipid II flippase MurJ

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-09658-0

Abstract: The biosynthesis of many polysaccharides, including bacterial peptidoglycan and eukaryotic N-linked glycans, requires transport of lipid-linked oligosaccharide (LLO) precursors across the membrane by specialized flippases. MurJ is the flippase for the lipid-linked peptidoglycan precursor Lipid… read more here.

Keywords: transitions lipid; visualizing conformation; flippase; conformation transitions ... See more keywords

Inefficient development of syncytiotrophoblasts in the Atp11a-deficient mouse placenta

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2200582119

Abstract: Significance Plasma membranes are composed of a lipid bilayer in which phosphatidylserine (PtdSer) is confined to the inner leaflet by the action of flippase that translocates PtdSer from the outer to inner leaflets. Two P4-ATPases… read more here.

Keywords: mouse placenta; flippase; deficient mouse; atp11a deficient ... See more keywords
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C-terminus of the P4-ATPase ATP8A2 functions in protein folding and regulation of phospholipid flippase activity

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recommendations! Published in 2017 at "Molecular Biology of the Cell"

DOI: 10.1091/mbc.e16-06-0453

Abstract: ATP8A2, an ATP-dependent phosphatidylserine flippase, generates and maintains membrane lipid asymmetry and has been linked to severe neurodegenerative disorders. The C-terminus of ATP8A2 promotes proper protein folding and regulates phosphatidylserine flippase activity. read more here.

Keywords: atpase atp8a2; flippase activity; terminus atpase; flippase ... See more keywords

TAT-1, a phosphatidylserine flippase, affects molting and regulates membrane trafficking in the epidermis of C. elegans.

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recommendations! Published in 2024 at "Genetics"

DOI: 10.1093/genetics/iyae216

Abstract: Membrane trafficking is a conserved process required for import, export, movement, and distribution of proteins and other macromolecules within cells. The Caenorhabditis elegans NIMA-related kinases NEKL-2 (human NEK8/9) and NEKL-3 (human NEK6/7) are conserved regulators… read more here.

Keywords: tat phosphatidylserine; flippase affects; flippase; rme ... See more keywords

Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance

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recommendations! Published in 2018 at "mBio"

DOI: 10.1128/mbio.01659-18

Abstract: Ever since daptomycin was introduced to the clinic, daptomycin-resistant isolates have been reported. In most cases, the resistant isolates harbor point mutations in MprF, which produces and flips the positively charged phospholipid LysPG. This has… read more here.

Keywords: mechanism; flippase; mprf; resistance ... See more keywords