C-terminus of the P4-ATPase ATP8A2 functions in protein folding and regulation of phospholipid flippase activity
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DOI: 10.1091/mbc.e16-06-0453
Abstract: ATP8A2, an ATP-dependent phosphatidylserine flippase, generates and maintains membrane lipid asymmetry and has been linked to severe neurodegenerative disorders. The C-terminus of ATP8A2 promotes proper protein folding and regulates phosphatidylserine flippase activity. read more here.
Keywords: atpase atp8a2; flippase activity; terminus atpase; flippase ... See more keywords
Not so Rare, Not so Mild Disease: Defects of Flippase Activity Due to ATP11C Mutations. Description of Three New Cases
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DOI: 10.1182/blood-2024-204922
Abstract: Introduction. The red blood cell (RBC) lipid bilayer is composed of equal proportions of cholesterol and phospholipids, these latter asymmetrically disposed through the activity of transport proteins: the flippases family (from the outer to the… read more here.
Keywords: hemolysis; defects flippase; flippase activity; three new ... See more keywords