Sign Up to like & get
recommendations!
0
Published in 2019 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.9b00582
Abstract: Among the >120 modified ribonucleosides in the prokaryotic epitranscriptome, many tRNA modifications are critical to bacterial survival, which makes their synthetic enzymes ideal targets for antibiotic development. Here we performed a structure-based design of inhibitors…
read more here.
Keywords:
trmd;
thienopyrimidinone derivatives;
tyrosine flipping;
active site ... See more keywords