A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
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DOI: 10.1038/s41467-018-06751-8
Abstract: Homeostatic regulation of G-quadruplexes (G4s), four-stranded structures that can form in guanine-rich nucleic acids, requires G4 unwinding helicases. The mechanisms that mediate G4 unwinding remain unknown. We report the structure of a bacterial RecQ DNA… read more here.
Keywords: flipping sequestration; sequestration mechanism; recq; guanine flipping ... See more keywords