Gene therapy with Pellino-1 improves perfusion and decreases tissue loss in Flk-1 heterozygous mice but fails in MAPKAP Kinase-2 knockout murine hind limb ischemia model.
Sign Up to like & getrecommendations! Published in 2022 at "Microvascular research"
DOI: 10.1016/j.mvr.2022.104311
Abstract: OBJECTIVES In the United States, over 8.5 million people suffer from peripheral arterial disease (PAD). Previously we reported that Pellino-1(Peli1) gene therapy reduces ischemic damage in the myocardium and skin flaps in Flk-1 [Fetal Liver… read more here.
Keywords: perfusion; gene therapy; mice; flk ... See more keywords
Abstract 15314: Gene Therapy With Pellino1 Improves Perfusion and Decreases Tissue Loss in an Flk-1 Heterozygous Murine Limb Ischemia Model But Fails in Mapkapkinase 2 Knockout Mice
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.15314
Abstract: Introduction: Peripheral vascular disease (PVD) is a major cause of morbidity in the US. Vascular endothelial growth factor (VEGF) induces angiogenesis through Fetal-Liver Kinase-1 (Flk-1 or VEGFR-2), an endothelial tyrosine kinase receptor which activates a… read more here.
Keywords: flk; mice; ischemia; limb ... See more keywords