Variantes que mantienen el marco de lectura en el dominio Rod 1 proximal del gen FLNA se asocian con un predominio del fenotipo valvular
Sign Up to like & getrecommendations! Published in 2018 at "Revista Espanola De Cardiologia"
DOI: 10.1016/j.recesp.2017.10.007
Abstract: Resumen Introduccion y objetivos La displasia valvular cardiaca ligada al cromosoma X es una cardiopatia congenita rara especifica del sexo masculino y caracterizada principalmente por una degeneracion mixomatosa de las valvulas auriculoventriculares con consecuencias hemodinamicas… read more here.
Keywords: flna; del; dominio rod; con ... See more keywords
Identification of Filamin A Mechanobinding Partner III: SAV1 Specifically Interacts with Filamin A Mechanosensitive Domain 21.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00665
Abstract: Filamin A (FLNA) cross-links actin filaments and mediates mechanotransduction by force-induced conformational changes of its domains. FLNA's mechanosensitive immunoglobulin-like repeats (R) interact with each other to create cryptic binding sites, which can be exposed by… read more here.
Keywords: specifically interacts; interaction; flna; sav1 specifically ... See more keywords
TRIP13/FLNA Complex Promotes Tumor Progression and Is Associated with Unfavorable Outcomes in Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/1419179
Abstract: Cutaneous melanoma is a high-grade malignant tumor originating from skin melanocytes with high risk of recurrence and metastasis. Further study on the mechanism of melanoma development is urgently needed. Here, we performed a bioinformatic analysis… read more here.
Keywords: melanoma; trip13; flna; melanoma cells ... See more keywords
Where the congenital heart disease meets the pulmonary arterial hypertension, FLNA matters: a case report and literature review
Sign Up to like & getrecommendations! Published in 2020 at "BMC Pediatrics"
DOI: 10.1186/s12887-020-02393-2
Abstract: Background Pediatric patients with genetic disorders have a higher incidence of pulmonary arterial hypertension (PAH) regardless of their heart defects. Filamin A ( FLNA ) mutation is recently recognized to be associated with pediatric pulmonary… read more here.
Keywords: heart; arterial hypertension; case; pulmonary arterial ... See more keywords
Filamin A is reduced and contributes to the CASR sensitivity in human parathyroid tumors.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-16-0184
Abstract: Parathyroid tumors display reduced sensitivity to extracellular calcium ([Ca2+]o). [Ca2+]o activates calcium-sensing receptor (CASR), which interacts with the scaffold protein filamin A (FLNA). The study aimed to investigate: (1) the FLNA expression in human parathyroid… read more here.
Keywords: parathyroid; sensitivity; expression; casr ... See more keywords
Interaction of LARP4 to filamin A mechanosensing domain regulates cell migrations
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1152109
Abstract: Filamin A (FLNA) is an actin cross-linking protein that mediates mechanotransduction. Force-dependent conformational changes of FLNA molecule expose cryptic binding site of FLNA, allowing interaction with partners such as integrin, smoothelin, and fimbacin. Here, we… read more here.
Keywords: interaction; flna; larp4; interaction larp4 ... See more keywords