Design and optimization of gastro‐floating sustained‐release tablet of pregabalin: In vitro and in vivo evaluation
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DOI: 10.1016/j.ijpharm.2018.04.011
Abstract: ABSTRACT Pregabalin is a promising drug for the treatment of neuropathic pain, a chronic disease affecting a large population needing long‐term treatment. However, due to its short half‐life, the commercial tablet has to be administered… read more here.
Keywords: gastro floating; sustained release; floating tablet; tablet ... See more keywords
Novel self-floating tablet for enhanced oral bioavailability of metformin based on cellulose.
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DOI: 10.1016/j.ijpharm.2020.120113
Abstract: Metformin has several problems such as low bioavailability, short half-life, and narrow absorption window, sustained and site-specific drug delivery system is required. Floating drug delivery systems are very useful to achieve these purposes. However, conventional… read more here.
Keywords: hcft; bioavailability; floating tablet; bioavailability metformin ... See more keywords
Development and Evaluation of Compression Coating Gastro-Floating Tablet of Alfuzosin Hydrochloride for Zero-Order Controlled Release
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DOI: 10.1208/s12249-018-1168-z
Abstract: ABSTRACTAlfuzosin hydrochloride is an appropriate candidate drug to prepare a gastro-retention controlled release dosage form since it demonstrates a narrow absorption window in the proximal section of the gastrointestinal tract with a short half-life. The… read more here.
Keywords: gastro floating; compression coating; floating tablet; alfuzosin hydrochloride ... See more keywords
In Vivo Evaluation of Thiamine Hydrochloride with Gastro-Retentive Drug Delivery in Healthy Human Volunteers Using Gamma Scintigraphy
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DOI: 10.3390/pharmaceutics15020691
Abstract: A floating tablet system containing thiamine hydrochloride, a model drug with a narrow absorption window, was evaluated. The tablet was found to have a floating lag time of less than 30 s with a sustained… read more here.
Keywords: thiamine; state; gastro retentive; tablet ... See more keywords