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Published in 2023 at "International journal of cancer"
DOI: 10.1002/ijc.34511
Abstract: In 2019, the FLOT4 protocol was established as the new standard for perioperative therapy in patients with locally advanced gastroesophageal and gastric cancer. Whether this protocol is beneficial in a real-world setting remains a question…
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Keywords:
perioperative therapy;
therapy;
gastroesophageal gastric;
flot ... See more keywords
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Published in 2017 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/nrclinonc.2016.186
Abstract: early stage gastric tumours (T1), but those with advanced-stage tumours (T2–4) or regional lymph-node involvement have a poor prognosis. Perioperative chemotherapy regimens containing epirubicin, cisplatin and fluorouracil (ECF) or epirubicin, cisplatin and capecitabine (ECX) can…
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Keywords:
ecf ecx;
group;
gastrointestinal cancer;
cancer keeping ... See more keywords
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1
Published in 2022 at "Diseases of the Esophagus"
DOI: 10.1093/dote/doac058
Abstract: Abstract Locally advanced esophageal adenocarcinomas (EACs) are treated with multimodal therapy, namely surgery, neoadjuvant chemotherapy (NAC) or chemoradiotherapy (CRT) depending on patient and tumor level factors. Yet, there is little consensus on choice of the…
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Keywords:
meta analysis;
review;
pcr rates;
flot ... See more keywords
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1
Published in 2022 at "Annals of surgery"
DOI: 10.1097/sla.0000000000005394
Abstract: Objective This study aimed to compare the postoperative and pathological outcomes between CROSS and FLOT in esophageal adenocarcinoma (EAC) patients from an international, multicenter cohort. Summary of Background Data Ongoing debate exists around optimum approach…
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Keywords:
study;
adenocarcinoma;
therapy;
cross flot ... See more keywords
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1
Published in 2022 at "Annals of Surgery"
DOI: 10.1097/sla.0000000000005617
Abstract: Background: The FLOT protocol and the CROSS trimodality regimen represent current standards in the management of locally advanced esophageal adenocarcinoma. In the absence of published Randomised Controlled Trial data, this propensity-matched comparison evaluated tolerance, toxicity,…
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Keywords:
cross;
flot;
cross versus;
flot cross ... See more keywords
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1
Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2022-060983
Abstract: Objective The perioperative chemotherapy with fluorouracil, leucovorin, oxaliplatin plus docetaxel (FLOT) was recommended by the Chinese Society of Clinical Oncology Guidelines for gastric cancer (2018 edition) for patients with resectable gastric or gastro-oesophageal junction adenocarcinoma…
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Keywords:
gastric gastro;
resectable gastric;
ecf ecx;
flot ... See more keywords
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0
Published in 2022 at "Case Reports in Gastroenterology"
DOI: 10.1159/000520057
Abstract: Gastric cancer (GC) represents one of the most fatal neoplasms in gastrointestinal oncology and affected patients can only hope for cure in limited disease. In a metastatic situation however, patients have a worse prognosis finally…
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Keywords:
her2;
flot;
trastuzumab;
cure ... See more keywords
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Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-122670
Abstract: Introduction The role of the bone marrow (BM) microenvironment (BMM) for the regulation of leukaemic stem cells (LSC) and their respective interplay is slowly being elucidated, but knowledge about how membrane structures or adhesion molecules…
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Keywords:
cd44;
flot;
role;
myeloid ... See more keywords
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0
Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.e16020
Abstract: e16020 Background: Docetaxel-based neoadjuvant chemotherapy has been suggested to be beneficial in patients with locally advanced gastric and gastro-oesophageal junction cancer (GC/GEJC). And immunotherapy also show promising treatment efficacy for advanced GC/GEJC. Here we compared…
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Keywords:
locally advanced;
efficacy;
treatment;
arm ... See more keywords
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Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.e16061
Abstract: e16061 Background: Based on results German FLOT-4 study, the FLOT regimen could be considered the new standard chemotherapy regimen for perioperative strategy of resectable GC. Since more and more patients have received neoadjuvant treatment,the efficacy…
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Keywords:
first group;
efficacy;
second group;
group patients ... See more keywords
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Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.3_suppl.201
Abstract: 201Background: ICONIC is a single-arm phase II trial investigating the safety and efficacy of perioperative FLOT-A in resectable OGA. Following a 3+3 design safety run-in phase, standard dose FLOT ...
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Keywords:
oga;
flot resectable;
perioperative flot;
trial ... See more keywords