Perioperative Therapy with Flot4 Significantly Increases Survival in Patients with Gastroesophageal and Gastric Cancer in A Large Real-World Cohort.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of cancer"
DOI: 10.1002/ijc.34511
Abstract: In 2019, the FLOT4 protocol was established as the new standard for perioperative therapy in patients with locally advanced gastroesophageal and gastric cancer. Whether this protocol is beneficial in a real-world setting remains a question… read more here.
Keywords: perioperative therapy; therapy; gastroesophageal gastric; flot ... See more keywords
Impact of perioperative fluorouracil, leucovorin, oxaliplatin, and docetaxel delivery on postoperative survival in locally advanced oesophagogastric adenocarcinoma
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DOI: 10.1007/s10120-025-01643-5
Abstract: Perioperative fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) is the standard of care for locally advanced oesophagogastric adenocarcinoma (LA-OGA) in Western countries. However, completing treatment is challenging for patients, particularly in the postoperative setting. This study… read more here.
Keywords: survival; perioperative fluorouracil; act; impact ... See more keywords
Gastrointestinal cancer: Keeping aFLOaT with new combination
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/nrclinonc.2016.186
Abstract: early stage gastric tumours (T1), but those with advanced-stage tumours (T2–4) or regional lymph-node involvement have a poor prognosis. Perioperative chemotherapy regimens containing epirubicin, cisplatin and fluorouracil (ECF) or epirubicin, cisplatin and capecitabine (ECX) can… read more here.
Keywords: ecf ecx; group; gastrointestinal cancer; cancer keeping ... See more keywords
Evaluation of tumor regression by neoadjuvant chemotherapy regimens for esophageal adenocarcinoma: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Diseases of the Esophagus"
DOI: 10.1093/dote/doac058
Abstract: Abstract Locally advanced esophageal adenocarcinomas (EACs) are treated with multimodal therapy, namely surgery, neoadjuvant chemotherapy (NAC) or chemoradiotherapy (CRT) depending on patient and tumor level factors. Yet, there is little consensus on choice of the… read more here.
Keywords: meta analysis; review; pcr rates; flot ... See more keywords
523. FIVE YEARS OF FLOT THERAPY. RANDOMIZED CONTROLLED TRIAL EVIDENCE IN PRACTICE
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DOI: 10.1093/dote/doae057.257
Abstract: The combination of 5-flurouracil, oxaliplatin, leucovorin and docetaxel (FLOT) is an effective chemotherapy regime in locally advanced, resectable gastro-oesophageal adenocarcinoma. Since the FLOT4-AIO randomised controlled trial demonstrated superiority over ECF/ECX it has been standard of… read more here.
Keywords: survival; five years; chemotherapy; flot ... See more keywords
Postoperative and Pathological Outcomes of CROSS and FLOT as Neoadjuvant Therapy for Esophageal and Junctional Adenocarcinoma: An International Cohort Study from the Oesophagogastric Anastomosis Audit (OGAA).
Sign Up to like & getrecommendations! Published in 2022 at "Annals of surgery"
DOI: 10.1097/sla.0000000000005394
Abstract: Objective This study aimed to compare the postoperative and pathological outcomes between CROSS and FLOT in esophageal adenocarcinoma (EAC) patients from an international, multicenter cohort. Summary of Background Data Ongoing debate exists around optimum approach… read more here.
Keywords: study; adenocarcinoma; therapy; cross flot ... See more keywords
CROSS Versus FLOT Regimens in Esophageal and Esophagogastric Junction Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Surgery"
DOI: 10.1097/sla.0000000000005617
Abstract: Background: The FLOT protocol and the CROSS trimodality regimen represent current standards in the management of locally advanced esophageal adenocarcinoma. In the absence of published Randomised Controlled Trial data, this propensity-matched comparison evaluated tolerance, toxicity,… read more here.
Keywords: cross; flot; cross versus; flot cross ... See more keywords
Economic evaluation of FLOT and ECF/ECX perioperative chemotherapy in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma
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DOI: 10.1136/bmjopen-2022-060983
Abstract: Objective The perioperative chemotherapy with fluorouracil, leucovorin, oxaliplatin plus docetaxel (FLOT) was recommended by the Chinese Society of Clinical Oncology Guidelines for gastric cancer (2018 edition) for patients with resectable gastric or gastro-oesophageal junction adenocarcinoma… read more here.
Keywords: gastric gastro; resectable gastric; ecf ecx; flot ... See more keywords
Cure Is Possible: Extensively Metastatic HER2-Positive Gastric Carcinoma with 5 years of Complete Remission after Therapy with the FLOT Regimen and Trastuzumab
Sign Up to like & getrecommendations! Published in 2022 at "Case Reports in Gastroenterology"
DOI: 10.1159/000520057
Abstract: Gastric cancer (GC) represents one of the most fatal neoplasms in gastrointestinal oncology and affected patients can only hope for cure in limited disease. In a metastatic situation however, patients have a worse prognosis finally… read more here.
Keywords: her2; flot; trastuzumab; cure ... See more keywords
The Role of the Lipid Raft-Associated Protein Flotillin-2 during Development and Progression of Myeloid Leukaemia
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DOI: 10.1182/blood-2019-122670
Abstract: Introduction The role of the bone marrow (BM) microenvironment (BMM) for the regulation of leukaemic stem cells (LSC) and their respective interplay is slowly being elucidated, but knowledge about how membrane structures or adhesion molecules… read more here.
Keywords: cd44; flot; role; myeloid ... See more keywords
Efficacy and safety of camrelizumab combined with FLOT versus FLOT alone as neoadjuvant therapy in patients with resectable locally advanced gastric and gastroesophageal junction adenocarcinoma who received D2 radical gastrectomy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.e16020
Abstract: e16020 Background: Docetaxel-based neoadjuvant chemotherapy has been suggested to be beneficial in patients with locally advanced gastric and gastro-oesophageal junction cancer (GC/GEJC). And immunotherapy also show promising treatment efficacy for advanced GC/GEJC. Here we compared… read more here.
Keywords: locally advanced; efficacy; treatment; arm ... See more keywords