N6-methyladenosine Demethylase FTO Induces the Dysfunctions of Ovarian Granulosa Cells by Upregulating Flotillin 2
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DOI: 10.1007/s43032-021-00664-6
Abstract: Polycystic ovarian syndrome (PCOS) is often accompanied by overweight/obesity and insulin resistance. The dysfunctions of ovarian granulosa cells (GCs) are closely linked with the pathogenesis of PCOS. Fat mass and obesity-associated gene (FTO), an N6-methyladenosine… read more here.
Keywords: ovarian granulosa; flot2; insulin resistance; dysfunctions ovarian ... See more keywords
Abstract 2506: Flotillin 2 negatively regulates EGFR phosphorylation and Cbl-mediated ubiquitination and degradation
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DOI: 10.1158/1538-7445.am2018-2506
Abstract: EGF receptor (EGFR) signaling is dysregulated by gene amplification or activating mutations of the EGFR in a variety of human malignancies. Activation of the EGFR by EGF leads to recruitment of the ubiquitin ligase Cbl,… read more here.
Keywords: degradation; cbl; flot2; egf stimulation ... See more keywords